Summary | |
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Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00431 CUB domain PF01759 UNC-6/NTR/C345C module |
Function |
Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. |
Biological Process |
GO:0010952 positive regulation of peptidase activity GO:0045862 positive regulation of proteolysis GO:0052547 regulation of peptidase activity |
Molecular Function |
GO:0005518 collagen binding GO:0005539 glycosaminoglycan binding GO:0008047 enzyme activator activity GO:0008201 heparin binding GO:0016504 peptidase activator activity GO:0061134 peptidase regulator activity GO:1901681 sulfur compound binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization |
Summary | |
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Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PCOLCE2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PCOLCE2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PCOLCE2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PCOLCE2 in various data sets.
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Summary | |
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Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PCOLCE2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PCOLCE2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PCOLCE2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PCOLCE2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PCOLCE2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PCOLCE2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PCOLCE2 |
Name | procollagen C-endopeptidase enhancer 2 |
Aliases | PCPE2; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2; PCPE-2 |
Chromosomal Location | 3q21-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PCOLCE2 collected from DrugBank database. |
There is no record. |