Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle. Secreted Note=Localized in the secretion granules. |
Domain |
PF01483 Proprotein convertase P-domain PF00082 Subtilase family PF16470 Peptidase S8 pro-domain |
Function |
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. |
Biological Process |
GO:0010817 regulation of hormone levels GO:0016485 protein processing GO:0016486 peptide hormone processing GO:0016540 protein autoprocessing GO:0030070 insulin processing GO:0034230 enkephalin processing GO:0034231 islet amyloid polypeptide processing GO:0042445 hormone metabolic process GO:0051604 protein maturation GO:1901142 insulin metabolic process |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0030133 transport vesicle GO:0030141 secretory granule GO:0030425 dendrite GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0044297 cell body GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-264876: Insulin processing R-HSA-392499: Metabolism of proteins R-HSA-2980736: Peptide hormone metabolism |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PCSK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PCSK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PCSK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PCSK2 in various data sets.
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Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PCSK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PCSK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PCSK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PCSK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PCSK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PCSK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PCSK2 |
Name | proprotein convertase subtilisin/kexin type 2 |
Aliases | SPC2; neuroendocrine convertase 2; KEX2-like endoprotease 2; NEC2; NEC 2; NEC-2; prohormone convertase 2; Pr ...... |
Chromosomal Location | 20p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PCSK2 collected from DrugBank database. |
Details on drugs targeting PCSK2.
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