Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 3: Secreted ; SUBCELLULAR LOCATION: Isoform 2: Endomembrane system Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 1: Cell membrane Single-pass type I membrane protein |
Domain |
PF08205 CD80-like C2-set immunoglobulin domain |
Function |
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0032609 interferon-gamma production GO:0032613 interleukin-10 production GO:0032649 regulation of interferon-gamma production GO:0032653 regulation of interleukin-10 production GO:0032689 negative regulation of interferon-gamma production GO:0032693 negative regulation of interleukin-10 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0045785 positive regulation of cell adhesion GO:0046006 regulation of activated T cell proliferation GO:0046007 negative regulation of activated T cell proliferation GO:0046651 lymphocyte proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050798 activated T cell proliferation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-388841: Costimulation by the CD28 family R-HSA-168256: Immune System R-HSA-389948: PD-1 signaling |
Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PDCD1LG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PDCD1LG2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PDCD1LG2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PDCD1LG2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PDCD1LG2 in various data sets.
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Summary | |
---|---|
Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDCD1LG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDCD1LG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDCD1LG2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDCD1LG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PDCD1LG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PDCD1LG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PDCD1LG2 |
Name | programmed cell death 1 ligand 2 |
Aliases | PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC; B7 dendritic cell molecule; B7DC; PDCD1L2; PD-1 ligand 2; PD-1- ...... |
Chromosomal Location | 9p24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PDCD1LG2 collected from DrugBank database. |
There is no record. |