TISIDB

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF00233 3'5'-cyclic nucleotide phosphodiesterase PF08499 3'5'-cyclic nucleotide phosphodiesterase N-terminal
Function	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

> Gene Ontology [ TOP ]
Biological Process	GO:0006195 purine nucleotide catabolic process GO:0006198 cAMP catabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009154 purine ribonucleotide catabolic process GO:0009166 nucleotide catabolic process GO:0009187 cyclic nucleotide metabolic process GO:0009214 cyclic nucleotide catabolic process GO:0009261 ribonucleotide catabolic process GO:0010657 muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0019439 aromatic compound catabolic process GO:0033002 muscle cell proliferation GO:0034390 smooth muscle cell apoptotic process GO:0034391 regulation of smooth muscle cell apoptotic process GO:0034655 nucleobase-containing compound catabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046058 cAMP metabolic process GO:0046068 cGMP metabolic process GO:0046069 cGMP catabolic process GO:0046434 organophosphate catabolic process GO:0046700 heterocycle catabolic process GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0072523 purine-containing compound catabolic process GO:1901136 carbohydrate derivative catabolic process GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process
Molecular Function	GO:0004112 cyclic-nucleotide phosphodiesterase activity GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0005516 calmodulin binding GO:0008081 phosphoric diester hydrolase activity GO:0019001 guanyl nucleotide binding GO:0030551 cyclic nucleotide binding GO:0030553 cGMP binding GO:0032561 guanyl ribonucleotide binding GO:0042578 phosphoric ester hydrolase activity GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
Cellular Component	GO:0043025 neuronal cell body GO:0044297 cell body

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04020 Calcium signaling pathway hsa04740 Olfactory transduction hsa04742 Taste transduction hsa00230 Purine metabolism
Reactome	R-HSA-111996: Ca-dependent events R-HSA-111997: CaM pathway R-HSA-111933: Calmodulin induced events R-HSA-111957: Cam-PDE 1 activation R-HSA-1489509: DAG and IP3 signaling R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-186763: Downstream signal transduction R-HSA-212718: EGFR interacts with phospholipase C-gamma R-HSA-418555: G alpha (s) signalling events R-HSA-112040: G-protein mediated events R-HSA-388396: GPCR downstream signaling R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-392154: Nitric oxide stimulates guanylate cyclase R-HSA-111885: Opioid Signalling R-HSA-112043: PLC beta mediated events R-HSA-167021: PLC-gamma1 signalling R-HSA-418346: Platelet homeostasis R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-186797: Signaling by PDGF R-HSA-166520: Signalling by NGF R-HSA-418457: cGMP effects

> KEGG and Reactome Pathway

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KEGG

hsa04020 Calcium signaling pathway
hsa04740 Olfactory transduction
hsa04742 Taste transduction
hsa00230 Purine metabolism

Reactome

R-HSA-111996: Ca-dependent events
R-HSA-111997: CaM pathway
R-HSA-111933: Calmodulin induced events
R-HSA-111957: Cam-PDE 1 activation
R-HSA-1489509: DAG and IP3 signaling
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-186763: Downstream signal transduction
R-HSA-212718: EGFR interacts with phospholipase C-gamma
R-HSA-418555: G alpha (s) signalling events
R-HSA-112040: G-protein mediated events
R-HSA-388396: GPCR downstream signaling
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-392154: Nitric oxide stimulates guanylate cyclase
R-HSA-111885: Opioid Signalling
R-HSA-112043: PLC beta mediated events
R-HSA-167021: PLC-gamma1 signalling
R-HSA-418346: Platelet homeostasis
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-186797: Signaling by PDGF
R-HSA-166520: Signalling by NGF
R-HSA-418457: cGMP effects

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PDE1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PDE1A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PDE1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.147	0.71
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.076	0.916
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.2	0.734
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.406	0.408
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.561	0.73
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.22	0.903
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.03	0.955
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.178	0.23
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	1.276	0.264
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.375	0.672
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.478	0.204
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.601	0.00106

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PDE1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	4.1	7	0.339
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	5.1	6	0.373
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	11.8	2.5	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	18.2	-2.8	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDE1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDE1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDE1A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDE1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PDE1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PDE1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PDE1A
Name	phosphodiesterase 1A, calmodulin-dependent
Aliases	CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; 61 kDa Cam-PDE; cam-PDE 1A; Calcium/calmodulin-dependent 3',5'-cyclic nu ......
Chromosomal Location	2q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PDE1A collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting PDE1A.

ID	Name	Drug Type	Targets	#Targets
DB00201	Caffeine	Small Molecule	ADORA1, ADORA2A, ATM, ITPR1, ITPR2, ITPR3, PDE10A, PDE11A, PDE1A, ......	33
DB00622	Nicardipine	Small Molecule	ADRA1A, ADRA1B, ADRA1D, CACNA1C, CACNA1D, CACNA2D1, CACNB2, CHRM1, ......	14
DB01023	Felodipine	Small Molecule	CACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNA2D2, CACNB2, NR ......	12
DB01244	Bepridil	Small Molecule	ATP1A1, CACNA1A, CACNA1H, CACNA2D2, KCNH2, KCNQ1, PDE1A, PDE1B, TN ......	9
DB09283	Trapidil	Small Molecule	PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, P ......	21

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