Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Lipid-anchor. |
Domain |
PF01590 GAF domain PF00233 3'5'-cyclic nucleotide phosphodiesterase |
Function |
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme. |
Biological Process |
GO:0001654 eye development GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007223 Wnt signaling pathway, calcium modulating pathway GO:0007423 sensory organ development GO:0007601 visual perception GO:0007602 phototransduction GO:0007603 phototransduction, visible light GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0016055 Wnt signaling pathway GO:0016056 rhodopsin mediated signaling pathway GO:0022400 regulation of rhodopsin mediated signaling pathway GO:0035567 non-canonical Wnt signaling pathway GO:0042278 purine nucleoside metabolic process GO:0043010 camera-type eye development GO:0046037 GMP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0050953 sensory perception of light stimulus GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060041 retina development in camera-type eye GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0198738 cell-cell signaling by wnt GO:1901068 guanosine-containing compound metabolic process GO:1901657 glycosyl compound metabolic process |
Molecular Function |
GO:0004112 cyclic-nucleotide phosphodiesterase activity GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0008081 phosphoric diester hydrolase activity GO:0042578 phosphoric ester hydrolase activity GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005929 cilium GO:0031253 cell projection membrane GO:0031513 nonmotile primary cilium GO:0044441 ciliary part GO:0060170 ciliary membrane GO:0072372 primary cilium GO:0097381 photoreceptor disc membrane |
KEGG |
hsa04744 Phototransduction hsa00230 Purine metabolism |
Reactome |
R-HSA-2485179: Activation of the phototransduction cascade R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-4086398: Ca2+ pathway R-HSA-2514859: Inactivation, recovery and regulation of the phototransduction cascade R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-2514856: The phototransduction cascade R-HSA-2187338: Visual phototransduction |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PDE6B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PDE6B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PDE6B in various data sets.
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Points in the above scatter plot represent the mutation difference of PDE6B in various data sets.
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Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDE6B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDE6B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDE6B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDE6B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PDE6B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PDE6B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PDE6B |
Name | phosphodiesterase 6B, cGMP-specific, rod, beta |
Aliases | CSNB3; rd1; RP40; CSNBAD2; congenital stationary night blindness 3, autosomal dominant; PDEB; GMP-PDE beta; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PDE6B collected from DrugBank database. |
Details on drugs targeting PDE6B.
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