Browse PDGFRB

Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Domain PF07679 Immunoglobulin I-set domain
PF00047 Immunoglobulin domain
PF07714 Protein tyrosine kinase
Function

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001101 response to acid chemical
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0003338 metanephros morphogenesis
GO:0006022 aminoglycan metabolic process
GO:0006023 aminoglycan biosynthetic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006816 calcium ion transport
GO:0006979 response to oxidative stress
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0009636 response to toxic substance
GO:0010035 response to inorganic substance
GO:0010517 regulation of phospholipase activity
GO:0010518 positive regulation of phospholipase activity
GO:0010712 regulation of collagen metabolic process
GO:0010714 positive regulation of collagen metabolic process
GO:0010863 positive regulation of phospholipase C activity
GO:0010921 regulation of phosphatase activity
GO:0010922 positive regulation of phosphatase activity
GO:0010927 cellular component assembly involved in morphogenesis
GO:0010959 regulation of metal ion transport
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014706 striated muscle tissue development
GO:0014812 muscle cell migration
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016311 dephosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030239 myofibril assembly
GO:0030258 lipid modification
GO:0030335 positive regulation of cell migration
GO:0031032 actomyosin structure organization
GO:0032103 positive regulation of response to external stimulus
GO:0032355 response to estradiol
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032526 response to retinoic acid
GO:0032835 glomerulus development
GO:0032956 regulation of actin cytoskeleton organization
GO:0032963 collagen metabolic process
GO:0032964 collagen biosynthetic process
GO:0032965 regulation of collagen biosynthetic process
GO:0032967 positive regulation of collagen biosynthetic process
GO:0032970 regulation of actin filament-based process
GO:0033002 muscle cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0034405 response to fluid shear stress
GO:0035023 regulation of Rho protein signal transduction
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035051 cardiocyte differentiation
GO:0035303 regulation of dephosphorylation
GO:0035304 regulation of protein dephosphorylation
GO:0035306 positive regulation of dephosphorylation
GO:0035307 positive regulation of protein dephosphorylation
GO:0035441 cell migration involved in vasculogenesis
GO:0035733 hepatic stellate cell activation
GO:0035787 cell migration involved in kidney development
GO:0035788 cell migration involved in metanephros development
GO:0035789 metanephric mesenchymal cell migration
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035904 aorta development
GO:0035909 aorta morphogenesis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036119 response to platelet-derived growth factor
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0036296 response to increased oxygen levels
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0040017 positive regulation of locomotion
GO:0042542 response to hydrogen peroxide
GO:0042692 muscle cell differentiation
GO:0043010 camera-type eye development
GO:0043270 positive regulation of ion transport
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043583 ear development
GO:0043627 response to estrogen
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044236 multicellular organism metabolic process
GO:0044246 regulation of multicellular organismal metabolic process
GO:0044253 positive regulation of multicellular organismal metabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0045787 positive regulation of cell cycle
GO:0045834 positive regulation of lipid metabolic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045931 positive regulation of mitotic cell cycle
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048514 blood vessel morphogenesis
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048738 cardiac muscle tissue development
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051146 striated muscle cell differentiation
GO:0051272 positive regulation of cellular component movement
GO:0051493 regulation of cytoskeleton organization
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055003 cardiac myofibril assembly
GO:0055006 cardiac cell development
GO:0055007 cardiac muscle cell differentiation
GO:0055013 cardiac muscle cell development
GO:0055093 response to hyperoxia
GO:0060041 retina development in camera-type eye
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0060326 cell chemotaxis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060840 artery development
GO:0060973 cell migration involved in heart development
GO:0060976 coronary vasculature development
GO:0060977 coronary vasculature morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0060981 cell migration involved in coronary angiogenesis
GO:0060993 kidney morphogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0061437 renal system vasculature development
GO:0061438 renal system vasculature morphogenesis
GO:0061439 kidney vasculature morphogenesis
GO:0061440 kidney vasculature development
GO:0061448 connective tissue development
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070482 response to oxygen levels
GO:0070509 calcium ion import
GO:0070838 divalent metal ion transport
GO:0071670 smooth muscle cell chemotaxis
GO:0071897 DNA biosynthetic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072012 glomerulus vasculature development
GO:0072028 nephron morphogenesis
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072074 kidney mesenchyme development
GO:0072075 metanephric mesenchyme development
GO:0072102 glomerulus morphogenesis
GO:0072103 glomerulus vasculature morphogenesis
GO:0072104 glomerular capillary formation
GO:0072109 glomerular mesangium development
GO:0072110 glomerular mesangial cell proliferation
GO:0072111 cell proliferation involved in kidney development
GO:0072203 cell proliferation involved in metanephros development
GO:0072210 metanephric nephron development
GO:0072215 regulation of metanephros development
GO:0072216 positive regulation of metanephros development
GO:0072223 metanephric glomerular mesangium development
GO:0072224 metanephric glomerulus development
GO:0072239 metanephric glomerulus vasculature development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072273 metanephric nephron morphogenesis
GO:0072275 metanephric glomerulus morphogenesis
GO:0072276 metanephric glomerulus vasculature morphogenesis
GO:0072277 metanephric glomerular capillary formation
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072511 divalent inorganic cation transport
GO:0072537 fibroblast activation
GO:0072593 reactive oxygen species metabolic process
GO:0090068 positive regulation of cell cycle process
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0090218 positive regulation of lipid kinase activity
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:1900238 regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:1900274 regulation of phospholipase C activity
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:2000147 positive regulation of cell motility
GO:2000278 regulation of DNA biosynthetic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000489 regulation of hepatic stellate cell activation
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000589 regulation of metanephric mesenchymal cell migration
GO:2000591 positive regulation of metanephric mesenchymal cell migration
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004992 platelet activating factor receptor activity
GO:0005017 platelet-derived growth factor-activated receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0019199 transmembrane receptor protein kinase activity
GO:0019838 growth factor binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0038085 vascular endothelial growth factor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:0070851 growth factor receptor binding
Cellular Component GO:0005775 vacuolar lumen
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0016324 apical plasma membrane
GO:0030055 cell-substrate junction
GO:0043202 lysosomal lumen
GO:0045177 apical part of cell
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04020 Calcium signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04540 Gap junction
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PDGFRB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PDGFRB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PDGFRB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.250.00314
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.9010.335
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7680.582
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3840.388
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.640.799
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0560.987
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.350.549
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3560.833
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.260.895
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.210.546
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.7850.304
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4410.00193
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PDGFRB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDGFRB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDGFRB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDGFRB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDGFRB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PDGFRB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PDGFRB and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPDGFRB
Nameplatelet-derived growth factor receptor, beta polypeptide
Aliases JTK12; CD140b; PDGFR1; PDGFR; IBGC4; IMF1; KOGS; PDGFR-1; PENTT; CD140 antigen-like family member B; PDGF-R- ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PDGFRB collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PDGFRB.
ID Name Drug Type Targets #Targets
DB00102BecaplerminBiotechA2M, PDGFRA, PDGFRB3
DB00398SorafenibSmall MoleculeBRAF, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET10
DB00619ImatinibSmall MoleculeABL1, CSF1R, DDR1, KIT, NTRK1, PDGFRA, PDGFRB7
DB01254DasatinibSmall MoleculeABL1, ABL2, BCR, BTK, CSK, EPHA2, EPHA5, EPHB4, FGR, FRK, FYN, HSP ......22
DB01268SunitinibSmall MoleculeCSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB8
DB05014XL999Small MoleculeFGFR1, FGFR3, FLT3, KDR, PDGFRB5
DB05146XL820Small MoleculeKDR, KIT, PDGFRA, PDGFRB4
DB06589PazopanibSmall MoleculeFGF1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B310
DB06595MidostaurinSmall MoleculeFLT3, KDR, KIT, PDGFRA, PDGFRB, PRKCA6
DB08896RegorafenibSmall MoleculeABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, ......18
DB09221PolaprezincSmall MoleculeFLT1, HSP90AA1, HSP90AB1, IL3, IL6, NGF, PDGFRB, TNF8