Summary | |
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Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion matrix |
Domain |
PF00481 Protein phosphatase 2C |
Function |
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. |
Biological Process |
GO:0006084 acetyl-CoA metabolic process GO:0006085 acetyl-CoA biosynthetic process GO:0006086 acetyl-CoA biosynthetic process from pyruvate GO:0006090 pyruvate metabolic process GO:0006470 protein dephosphorylation GO:0006631 fatty acid metabolic process GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0009108 coenzyme biosynthetic process GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010565 regulation of cellular ketone metabolic process GO:0016311 dephosphorylation GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0035383 thioester metabolic process GO:0035384 thioester biosynthetic process GO:0035970 peptidyl-threonine dephosphorylation GO:0042180 cellular ketone metabolic process GO:0042762 regulation of sulfur metabolic process GO:0044272 sulfur compound biosynthetic process GO:0050812 regulation of acyl-CoA biosynthetic process GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0051193 regulation of cofactor metabolic process GO:0051196 regulation of coenzyme metabolic process GO:0071616 acyl-CoA biosynthetic process |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG | - |
Reactome |
R-HSA-1430728: Metabolism R-HSA-70268: Pyruvate metabolism R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-204174: Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PDP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PDP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PDP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PDP1 in various data sets.
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Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PDP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PDP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PDP1 |
Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
Aliases | PDP; PDH; PPM2C; protein phosphatase 2C, magnesium-dependent, catalytic subunit; PDPC; PDP 1; PDPC 1; [Pyruv ...... |
Chromosomal Location | 8q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PDP1 collected from DrugBank database. |
There is no record. |