Summary | |
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Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007064 mitotic sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0098813 nuclear chromosome segregation |
Molecular Function | - |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2470946: Cohesin Loading onto Chromatin R-HSA-2468052: Establishment of Sister Chromatid Cohesion R-HSA-68886: M Phase R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-68884: Mitotic Telophase/Cytokinesis R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-69242: S Phase R-HSA-2467813: Separation of Sister Chromatids |
Summary | |
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Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PDS5B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PDS5B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PDS5B in various data sets.
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Points in the above scatter plot represent the mutation difference of PDS5B in various data sets.
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Summary | |
---|---|
Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDS5B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDS5B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDS5B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDS5B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PDS5B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PDS5B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PDS5B |
Name | PDS5 cohesin associated factor B |
Aliases | AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ...... |
Chromosomal Location | 13q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PDS5B collected from DrugBank database. |
There is no record. |