Browse PDS5B

Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain -
Function

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000819 sister chromatid segregation
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0098813 nuclear chromosome segregation
Molecular Function -
Cellular Component GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-2470946: Cohesin Loading onto Chromatin
R-HSA-2468052: Establishment of Sister Chromatid Cohesion
R-HSA-68886: M Phase
R-HSA-68882: Mitotic Anaphase
R-HSA-2555396: Mitotic Metaphase and Anaphase
R-HSA-68877: Mitotic Prometaphase
R-HSA-68884: Mitotic Telophase/Cytokinesis
R-HSA-2500257: Resolution of Sister Chromatid Cohesion
R-HSA-69242: S Phase
R-HSA-2467813: Separation of Sister Chromatids
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PDS5B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PDS5B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PDS5B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0220.932
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0210.987
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.050.96
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0280.918
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1780.933
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.160.952
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0640.859
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1410.932
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0790.964
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2380.784
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9920.414
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1120.076
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PDS5B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.81.413.40.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.81.713.10.032
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDS5B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDS5B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDS5B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDS5B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PDS5B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PDS5B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPDS5B
NamePDS5 cohesin associated factor B
Aliases AS3; KIAA0979; FLJ23236; CG008; APRIN; androgen-induced proliferation inhibitor; PDS5, regulator of cohesion ......
Chromosomal Location13q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PDS5B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.