Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm, cytosol |
Domain |
PF00046 Homeobox domain |
Function |
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
Biological Process |
GO:0001101 response to acid chemical GO:0001678 cellular glucose homeostasis GO:0001889 liver development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002067 glandular epithelial cell differentiation GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0003309 type B pancreatic cell differentiation GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006091 generation of precursor metabolites and energy GO:0007224 smoothened signaling pathway GO:0007263 nitric oxide mediated signal transduction GO:0007568 aging GO:0007584 response to nutrient GO:0009306 protein secretion GO:0009730 detection of carbohydrate stimulus GO:0009732 detection of hexose stimulus GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010039 response to iron ion GO:0010040 response to iron(II) ion GO:0010157 response to chlorate GO:0010260 animal organ senescence GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0016331 morphogenesis of embryonic epithelium GO:0019318 hexose metabolic process GO:0019932 second-messenger-mediated signaling GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0031016 pancreas development GO:0031017 exocrine pancreas development GO:0031018 endocrine pancreas development GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032024 positive regulation of insulin secretion GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033273 response to vitamin GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0034287 detection of monosaccharide stimulus GO:0034976 response to endoplasmic reticulum stress GO:0035094 response to nicotine GO:0035270 endocrine system development GO:0035272 exocrine system development GO:0035773 insulin secretion involved in cellular response to glucose stimulus GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035883 enteroendocrine cell differentiation GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0043200 response to amino acid GO:0043201 response to leucine GO:0043279 response to alkaloid GO:0043388 positive regulation of DNA binding GO:0044723 single-organism carbohydrate metabolic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048545 response to steroid hormone GO:0048565 digestive tract development GO:0048732 gland development GO:0048863 stem cell differentiation GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051047 positive regulation of secretion GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051222 positive regulation of protein transport GO:0051384 response to glucocorticoid GO:0051594 detection of glucose GO:0055123 digestive system development GO:0060290 transdifferentiation GO:0061008 hepaticobiliary system development GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070542 response to fatty acid GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:0097050 type B pancreatic cell apoptotic process GO:0097193 intrinsic apoptotic signaling pathway GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1903532 positive regulation of secretion by cell GO:1903573 negative regulation of response to endoplasmic reticulum stress GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:1904951 positive regulation of establishment of protein localization GO:1990267 response to transition metal nanoparticle GO:2000674 regulation of type B pancreatic cell apoptotic process GO:2000675 negative regulation of type B pancreatic cell apoptotic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008134 transcription factor binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0016604 nuclear body GO:0016607 nuclear speck |
KEGG |
hsa04911 Insulin secretion |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-186712: Regulation of beta-cell development R-HSA-210745: Regulation of gene expression in beta cells R-HSA-210747: Regulation of gene expression in early pancreatic precursor cells |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PDX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of PDX1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PDX1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of PDX1 in various data sets.
|
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDX1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PDX1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PDX1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PDX1 |
Name | pancreatic and duodenal homeobox 1 |
Aliases | IDX-1; PDX-1; MODY4; somatostatin transcription factor 1; IPF1; insulin promoter factor 1, homeodomain trans ...... |
Chromosomal Location | 13q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PDX1 collected from DrugBank database. |
There is no record. |