Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Peroxisome membrane Cell projection, cilium, photoreceptor outer segment Note=Associated with peroxisomal membranes. Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). |
Domain |
PF00004 ATPase family associated with various cellular activities (AAA) |
Function |
Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. |
Biological Process |
GO:0006625 protein targeting to peroxisome GO:0007031 peroxisome organization GO:0016558 protein import into peroxisome matrix GO:0016561 protein import into peroxisome matrix, translocation GO:0017038 protein import GO:0031647 regulation of protein stability GO:0043574 peroxisomal transport GO:0044743 intracellular protein transmembrane import GO:0050821 protein stabilization GO:0065002 intracellular protein transmembrane transport GO:0071806 protein transmembrane transport GO:0072662 protein localization to peroxisome GO:0072663 establishment of protein localization to peroxisome |
Molecular Function |
GO:0008022 protein C-terminus binding GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled |
Cellular Component |
GO:0005777 peroxisome GO:0005778 peroxisomal membrane GO:0031903 microbody membrane GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part |
KEGG |
hsa04146 Peroxisome |
Reactome | - |
Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PEX6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PEX6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PEX6 in various data sets.
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Points in the above scatter plot represent the mutation difference of PEX6 in various data sets.
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Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PEX6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PEX6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PEX6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PEX6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PEX6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PEX6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PEX6 |
Name | peroxisomal biogenesis factor 6 |
Aliases | PXAAA1; PAF-2; PAF2; PBD4A; PDB4B; peroxin-6; peroxisomal AAA-type ATPase 1; peroxisomal-type ATPase 1; pero ...... |
Chromosomal Location | 6p22-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PEX6 collected from DrugBank database. |
There is no record. |