Summary | |
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Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Cytoplasmic granule |
Domain |
PF01510 N-acetylmuramoyl-L-alanine amidase |
Function |
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. |
Biological Process |
GO:0000270 peptidoglycan metabolic process GO:0001779 natural killer cell differentiation GO:0001818 negative regulation of cytokine production GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0002325 natural killer cell differentiation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006022 aminoglycan metabolic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0009253 peptidoglycan catabolic process GO:0009595 detection of biotic stimulus GO:0016045 detection of bacterium GO:0030098 lymphocyte differentiation GO:0030101 natural killer cell activation GO:0030203 glycosaminoglycan metabolic process GO:0031348 negative regulation of defense response GO:0031349 positive regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032609 interferon-gamma production GO:0032649 regulation of interferon-gamma production GO:0032689 negative regulation of interferon-gamma production GO:0032814 regulation of natural killer cell activation GO:0032815 negative regulation of natural killer cell activation GO:0032823 regulation of natural killer cell differentiation GO:0032824 negative regulation of natural killer cell differentiation GO:0032826 regulation of natural killer cell differentiation involved in immune response GO:0032827 negative regulation of natural killer cell differentiation involved in immune response GO:0042742 defense response to bacterium GO:0044110 growth involved in symbiotic interaction GO:0044116 growth of symbiont involved in interaction with host GO:0044117 growth of symbiont in host GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045619 regulation of lymphocyte differentiation GO:0045620 negative regulation of lymphocyte differentiation GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050777 negative regulation of immune response GO:0050830 defense response to Gram-positive bacterium GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0098542 defense response to other organism GO:0098543 detection of other organism GO:0098581 detection of external biotic stimulus GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis |
Molecular Function |
GO:0005539 glycosaminoglycan binding GO:0008329 signaling pattern recognition receptor activity GO:0008745 N-acetylmuramoyl-L-alanine amidase activity GO:0016019 peptidoglycan receptor activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0038187 pattern recognition receptor activity GO:0042834 peptidoglycan binding GO:0061783 peptidoglycan muralytic activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-6803157: Antimicrobial peptides R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
---|---|
Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PGLYRP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PGLYRP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PGLYRP1 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PGLYRP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PGLYRP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PGLYRP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PGLYRP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PGLYRP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PGLYRP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PGLYRP1 |
Name | peptidoglycan recognition protein 1 |
Aliases | TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PGLYRP1 collected from DrugBank database. |
There is no record. |