Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasmic vesicle Nucleus, nucleolus Note=Colocalizes with intracellular vesicles. |
Domain | - |
Function |
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. |
Biological Process |
GO:0000086 G2/M transition of mitotic cell cycle GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0045210 FasL biosynthetic process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-69275: G2/M Transition R-HSA-8854521: Interaction between PHLDA1 and AURKA R-HSA-453274: Mitotic G2-G2/M phases |
Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PHLDA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PHLDA1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PHLDA1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PHLDA1 in various data sets.
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Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PHLDA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PHLDA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PHLDA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PHLDA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PHLDA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PHLDA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PHLDA1 |
Name | pleckstrin homology-like domain, family A, member 1 |
Aliases | TDAG51; DT1P1B11; PHRIP; proline-histidine rich protein; PQ-rich protein; PQR protein; T-cell death-associat ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PHLDA1 collected from DrugBank database. |
There is no record. |