Summary | |
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Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane |
Domain |
PF13516 Leucine Rich repeat PF13855 Leucine rich repeat PF00169 PH domain PF00481 Protein phosphatase 2C |
Function |
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). |
Biological Process |
GO:0002249 lymphocyte anergy GO:0002507 tolerance induction GO:0002517 T cell tolerance induction GO:0002643 regulation of tolerance induction GO:0002664 regulation of T cell tolerance induction GO:0002667 regulation of T cell anergy GO:0002870 T cell anergy GO:0002911 regulation of lymphocyte anergy GO:0006470 protein dephosphorylation GO:0007254 JNK cascade GO:0007623 circadian rhythm GO:0009649 entrainment of circadian clock GO:0016311 dephosphorylation GO:0031098 stress-activated protein kinase signaling cascade GO:0032872 regulation of stress-activated MAPK cascade GO:0038066 p38MAPK cascade GO:0042752 regulation of circadian rhythm GO:0043491 protein kinase B signaling GO:0046328 regulation of JNK cascade GO:0048511 rhythmic process GO:0051403 stress-activated MAPK cascade GO:0051896 regulation of protein kinase B signaling GO:0051898 negative regulation of protein kinase B signaling GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:1900744 regulation of p38MAPK cascade GO:1902532 negative regulation of intracellular signal transduction |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component | - |
KEGG |
hsa04151 PI3K-Akt signaling pathway |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-180292: GAB1 signalosome R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-198203: PI3K/AKT activation R-HSA-1257604: PIP3 activates AKT signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF |
Summary | |
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Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PHLPP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PHLPP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PHLPP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PHLPP1 in various data sets.
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Summary | |
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Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PHLPP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PHLPP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PHLPP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PHLPP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PHLPP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PHLPP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PHLPP1 |
Name | PH domain and leucine rich repeat protein phosphatase 1 |
Aliases | KIAA0606; SCOP; PLEKHE1; PHLPP; pleckstrin homology domain containing, family E (with leucine rich repeats) ...... |
Chromosomal Location | 18q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PHLPP1 collected from DrugBank database. |
There is no record. |