Summary | |
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Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane, clathrin-coated pit Golgi apparatus Cytoplasmic vesicle, clathrin-coated vesicle Nucleus Note=Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). |
Domain |
PF07651 ANTH domain |
Function |
Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. |
Biological Process |
GO:0000041 transition metal ion transport GO:0006826 iron ion transport GO:0006898 receptor-mediated endocytosis GO:0007034 vacuolar transport GO:0007409 axonogenesis GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0016050 vesicle organization GO:0016188 synaptic vesicle maturation GO:0016197 endosomal transport GO:0016358 dendrite development GO:0021700 developmental maturation GO:0030100 regulation of endocytosis GO:0031623 receptor internalization GO:0034205 beta-amyloid formation GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0035459 cargo loading into vesicle GO:0042982 amyloid precursor protein metabolic process GO:0042987 amyloid precursor protein catabolic process GO:0043112 receptor metabolic process GO:0045806 negative regulation of endocytosis GO:0045861 negative regulation of proteolysis GO:0045862 positive regulation of proteolysis GO:0048259 regulation of receptor-mediated endocytosis GO:0048261 negative regulation of receptor-mediated endocytosis GO:0048268 clathrin coat assembly GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0050435 beta-amyloid metabolic process GO:0051051 negative regulation of transport GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055072 iron ion homeostasis GO:0055076 transition metal ion homeostasis GO:0060627 regulation of vesicle-mediated transport GO:0061564 axon development GO:0070997 neuron death GO:0072583 clathrin-dependent endocytosis GO:0097286 iron ion import GO:0097459 iron ion import into cell GO:0098657 import into cell GO:0098659 inorganic cation import into cell GO:0099587 inorganic ion import into cell GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1902003 regulation of beta-amyloid formation GO:1902004 positive regulation of beta-amyloid formation GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1902991 regulation of amyloid precursor protein catabolic process GO:1902992 negative regulation of amyloid precursor protein catabolic process GO:1902993 positive regulation of amyloid precursor protein catabolic process GO:1904683 regulation of metalloendopeptidase activity GO:1904684 negative regulation of metalloendopeptidase activity GO:1905048 regulation of metallopeptidase activity GO:1905049 negative regulation of metallopeptidase activity GO:1905245 regulation of aspartic-type peptidase activity GO:1905247 positive regulation of aspartic-type peptidase activity |
Molecular Function |
GO:0005543 phospholipid binding GO:0005545 1-phosphatidylinositol binding GO:0030276 clathrin binding GO:0030674 protein binding, bridging GO:0032050 clathrin heavy chain binding GO:0035091 phosphatidylinositol binding GO:0035615 clathrin adaptor activity GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0060090 binding, bridging GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion GO:0098748 endocytic adaptor activity |
Cellular Component |
GO:0005905 clathrin-coated pit GO:0005913 cell-cell adherens junction GO:0016234 inclusion body GO:0030117 membrane coat GO:0030118 clathrin coat GO:0030119 AP-type membrane coat adaptor complex GO:0030120 vesicle coat GO:0030122 AP-2 adaptor complex GO:0030125 clathrin vesicle coat GO:0030128 clathrin coat of endocytic vesicle GO:0030131 clathrin adaptor complex GO:0030132 clathrin coat of coated pit GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0042734 presynaptic membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0045211 postsynaptic membrane GO:0045334 clathrin-coated endocytic vesicle GO:0048475 coated membrane GO:0097060 synaptic membrane GO:0097418 neurofibrillary tangle GO:0098589 membrane region GO:0098793 presynapse GO:0098794 postsynapse |
KEGG | - |
Reactome |
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-421837: Clathrin derived vesicle budding R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-432722: Golgi Associated Vesicle Biogenesis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport R-HSA-199992: trans-Golgi Network Vesicle Budding |
Summary | |
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Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PICALM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PICALM in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PICALM in various data sets.
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Points in the above scatter plot represent the mutation difference of PICALM in various data sets.
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Summary | |
---|---|
Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PICALM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PICALM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PICALM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PICALM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PICALM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PICALM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PICALM |
Name | phosphatidylinositol binding clathrin assembly protein |
Aliases | CLTH; clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly pr ...... |
Chromosomal Location | 11q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PICALM collected from DrugBank database. |
There is no record. |