Summary | |
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Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF15917 Piezo PF12166 Piezo non-specific cation channel |
Function |
Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. |
Biological Process |
GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009612 response to mechanical stimulus GO:0050954 sensory perception of mechanical stimulus GO:0050974 detection of mechanical stimulus involved in sensory perception GO:0050982 detection of mechanical stimulus |
Molecular Function |
GO:0005216 ion channel activity GO:0008381 mechanically-gated ion channel activity GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022833 mechanically gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PIEZO2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PIEZO2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PIEZO2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PIEZO2 in various data sets.
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Summary | |
---|---|
Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIEZO2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIEZO2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIEZO2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIEZO2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PIEZO2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PIEZO2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PIEZO2 |
Name | piezo-type mechanosensitive ion channel component 2 |
Aliases | FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PIEZO2 collected from DrugBank database. |
There is no record. |