Browse PIGY

Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Multi-pass membrane protein
Domain PF15159 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Function

Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.

> Gene Ontology
 
Biological Process GO:0006497 protein lipidation
GO:0006505 GPI anchor metabolic process
GO:0006506 GPI anchor biosynthetic process
GO:0006643 membrane lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006664 glycolipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0009247 glycolipid biosynthetic process
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0045017 glycerolipid biosynthetic process
GO:0046467 membrane lipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:1903509 liposaccharide metabolic process
Molecular Function -
Cellular Component GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
> KEGG and Reactome Pathway
 
KEGG hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways
Reactome -
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PIGY and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PIGY in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PIGY in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6390.0286
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6870.823
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.6060.785
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91601
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 5901
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 4701
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7460.734
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0240.725
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 6823001
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIGY. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIGY. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIGY.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIGY. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PIGY expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PIGY and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPIGY
Namephosphatidylinositol glycan anchor biosynthesis, class Y
Aliases MGC14156; phosphatidylinositol glycan, class Y; PIG-Y; phosphatidylinositol-glycan biosynthesis class Y prot ......
Chromosomal Location4q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PIGY collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.