Summary | |
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Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF08190 pre-RNA processing PIH1/Nop17 |
Function |
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). |
Biological Process |
GO:0000491 small nucleolar ribonucleoprotein complex assembly GO:0000492 box C/D snoRNP assembly GO:0001678 cellular glucose homeostasis GO:0006338 chromatin remodeling GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006364 rRNA processing GO:0006403 RNA localization GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006479 protein methylation GO:0008213 protein alkylation GO:0009303 rRNA transcription GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009756 carbohydrate mediated signaling GO:0009757 hexose mediated signaling GO:0010182 sugar mediated signaling pathway GO:0010255 glucose mediated signaling pathway GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016072 rRNA metabolic process GO:0016570 histone modification GO:0016571 histone methylation GO:0016573 histone acetylation GO:0018022 peptidyl-lysine methylation GO:0018023 peptidyl-lysine trimethylation GO:0018027 peptidyl-lysine dimethylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031334 positive regulation of protein complex assembly GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032008 positive regulation of TOR signaling GO:0032259 methylation GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033500 carbohydrate homeostasis GO:0033674 positive regulation of kinase activity GO:0034284 response to monosaccharide GO:0034470 ncRNA processing GO:0034502 protein localization to chromosome GO:0034968 histone lysine methylation GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035067 negative regulation of histone acetylation GO:0036123 histone H3-K9 dimethylation GO:0036124 histone H3-K9 trimethylation GO:0038202 TORC1 signaling GO:0042254 ribosome biogenesis GO:0042593 glucose homeostasis GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043254 regulation of protein complex assembly GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043414 macromolecule methylation GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation GO:0043970 histone H3-K9 acetylation GO:0043984 histone H4-K16 acetylation GO:0044089 positive regulation of cellular component biogenesis GO:0045860 positive regulation of protein kinase activity GO:0045861 negative regulation of proteolysis GO:0045943 positive regulation of transcription from RNA polymerase I promoter GO:0048254 snoRNA localization GO:0051346 negative regulation of hydrolase activity GO:0051567 histone H3-K9 methylation GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061647 histone H3-K9 modification GO:0070199 establishment of protein localization to chromosome GO:0071168 protein localization to chromatin GO:0071169 establishment of protein localization to chromatin GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071826 ribonucleoprotein complex subunit organization GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090239 regulation of histone H4 acetylation GO:0090240 positive regulation of histone H4 acetylation GO:0090241 negative regulation of histone H4 acetylation GO:0098781 ncRNA transcription GO:1900109 regulation of histone H3-K9 dimethylation GO:1900110 negative regulation of histone H3-K9 dimethylation GO:1900112 regulation of histone H3-K9 trimethylation GO:1900113 negative regulation of histone H3-K9 trimethylation GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter GO:1901983 regulation of protein acetylation GO:1901984 negative regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902275 regulation of chromatin organization GO:1902659 regulation of glucose mediated signaling pathway GO:1902661 positive regulation of glucose mediated signaling pathway GO:1903432 regulation of TORC1 signaling GO:1904263 positive regulation of TORC1 signaling GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000615 regulation of histone H3-K9 acetylation GO:2000617 positive regulation of histone H3-K9 acetylation GO:2000618 regulation of histone H4-K16 acetylation GO:2000619 negative regulation of histone H4-K16 acetylation GO:2000756 regulation of peptidyl-lysine acetylation GO:2000757 negative regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Molecular Function |
GO:0001013 RNA polymerase I regulatory region DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding GO:0042393 histone binding GO:0051117 ATPase binding GO:0051219 phosphoprotein binding |
Cellular Component |
GO:0070761 pre-snoRNP complex GO:0097255 R2TP complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PIH1D1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PIH1D1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PIH1D1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PIH1D1 in various data sets.
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Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIH1D1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIH1D1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIH1D1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIH1D1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PIH1D1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PIH1D1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PIH1D1 |
Name | PIH1 domain containing 1 |
Aliases | FLJ20643; NOP17; nucleolar protein 17 homolog; PIH1 domain-containing protein 1 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PIH1D1 collected from DrugBank database. |
There is no record. |