Browse PIK3CA

Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00454 Phosphatidylinositol 3- and 4-kinase
PF00792 Phosphoinositide 3-kinase C2
PF02192 PI3-kinase family
PF00794 PI3-kinase family
PF00613 Phosphoinositide 3-kinase family
Function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001667 ameboidal-type cell migration
GO:0001678 cellular glucose homeostasis
GO:0001889 liver development
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006304 DNA modification
GO:0006305 DNA alkylation
GO:0006306 DNA methylation
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006909 phagocytosis
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007159 leukocyte cell-cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008286 insulin receptor signaling pathway
GO:0008654 phospholipid biosynthetic process
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0010631 epithelial cell migration
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0015980 energy derivation by oxidation of organic compounds
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0019318 hexose metabolic process
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030168 platelet activation
GO:0030258 lipid modification
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0032147 activation of protein kinase activity
GO:0032259 methylation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0034284 response to monosaccharide
GO:0035264 multicellular organism growth
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038093 Fc receptor signaling pathway
GO:0038094 Fc-gamma receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038127 ERBB signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0042110 T cell activation
GO:0042593 glucose homeostasis
GO:0043276 anoikis
GO:0043414 macromolecule methylation
GO:0043434 response to peptide hormone
GO:0043457 regulation of cellular respiration
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043491 protein kinase B signaling
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043542 endothelial cell migration
GO:0044028 DNA hypomethylation
GO:0044029 hypomethylation of CpG island
GO:0044030 regulation of DNA methylation
GO:0044346 fibroblast apoptotic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044728 DNA methylation or demethylation
GO:0045017 glycerolipid biosynthetic process
GO:0045333 cellular respiration
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048514 blood vessel morphogenesis
GO:0048638 regulation of developmental growth
GO:0048732 gland development
GO:0048871 multicellular organismal homeostasis
GO:0050817 coagulation
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0051052 regulation of DNA metabolic process
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051402 neuron apoptotic process
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060612 adipose tissue development
GO:0061008 hepaticobiliary system development
GO:0061448 connective tissue development
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070997 neuron death
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071514 genetic imprinting
GO:0071593 lymphocyte aggregation
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0097009 energy homeostasis
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:2000209 regulation of anoikis
GO:2000269 regulation of fibroblast apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000653 regulation of genetic imprinting
GO:2000811 negative regulation of anoikis
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0008047 enzyme activator activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0019207 kinase regulator activity
GO:0019209 kinase activator activity
GO:0019887 protein kinase regulator activity
GO:0030295 protein kinase activator activity
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560 insulin receptor substrate binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0052742 phosphatidylinositol kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
Cellular Component GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0019898 extrinsic component of membrane
GO:0030027 lamellipodium
GO:0031252 cell leading edge
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0097651 phosphatidylinositol 3-kinase complex, class I
> KEGG and Reactome Pathway
 
KEGG hsa04012 ErbB signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04066 HIF-1 signaling pathway
hsa04068 FoxO signaling pathway
hsa04070 Phosphatidylinositol signaling system
hsa04071 Sphingolipid signaling pathway
hsa04140 Regulation of autophagy
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04210 Apoptosis
hsa04360 Axon guidance
hsa04370 VEGF signaling pathway
hsa04380 Osteoclast differentiation
hsa04510 Focal adhesion
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04611 Platelet activation
hsa04620 Toll-like receptor signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04650 Natural killer cell mediated cytotoxicity
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa04668 TNF signaling pathway
hsa04670 Leukocyte transendothelial migration
hsa04722 Neurotrophin signaling pathway
hsa04725 Cholinergic synapse
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04810 Regulation of actin cytoskeleton
hsa04910 Insulin signaling pathway
hsa04914 Progesterone-mediated oocyte maturation
hsa04915 Estrogen signaling pathway
hsa04917 Prolactin signaling pathway
hsa04919 Thyroid hormone signaling pathway
hsa04960 Aldosterone-regulated sodium reabsorption
hsa04973 Carbohydrate digestion and absorption
hsa00562 Inositol phosphate metabolism
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-389356: CD28 co-stimulation
R-HSA-389357: CD28 dependent PI3K/Akt signaling
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-1500931: Cell-Cell communication
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5637810: Constitutive Signaling by EGFRvIII
R-HSA-1236382: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-388841: Costimulation by the CD28 family
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-202424: Downstream TCR signaling
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-5654708: Downstream signaling of activated FGFR3
R-HSA-5654716: Downstream signaling of activated FGFR4
R-HSA-1839124: FGFR1 mutant receptor activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-416482: G alpha (12/13) signalling events
R-HSA-416476: G alpha (q) signalling events
R-HSA-392451: G beta
R-HSA-397795: G-protein beta
R-HSA-180292: GAB1 signalosome
R-HSA-388396: GPCR downstream signaling
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-8851907: MET activates PI3K/AKT signaling
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-373753: Nephrin interactions
R-HSA-1483255: PI Metabolism
R-HSA-5654689: PI-3K cascade
R-HSA-5654695: PI-3K cascade
R-HSA-5654710: PI-3K cascade
R-HSA-5654720: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-1963642: PI3K events in ERBB2 signaling
R-HSA-1250342: PI3K events in ERBB4 signaling
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-1483257: Phospholipid metabolism
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-8853659: RET signaling
R-HSA-912631: Regulation of signaling by CBL
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2029485: Role of phospholipids in phagocytosis
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-1643713: Signaling by EGFR in Cancer
R-HSA-5637812: Signaling by EGFRvIII in Cancer
R-HSA-1227986: Signaling by ERBB2
R-HSA-1236394: Signaling by ERBB4
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654736: Signaling by FGFR1
R-HSA-5655302: Signaling by FGFR1 in disease
R-HSA-5654738: Signaling by FGFR2
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-5654741: Signaling by FGFR3
R-HSA-8853334: Signaling by FGFR3 fusions in cancer
R-HSA-5655332: Signaling by FGFR3 in disease
R-HSA-8853338: Signaling by FGFR3 point mutants in cancer
R-HSA-5654743: Signaling by FGFR4
R-HSA-5655291: Signaling by FGFR4 in disease
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-5637815: Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-6806834: Signaling by MET
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-1660499: Synthesis of PIPs at the plasma membrane
R-HSA-202403: TCR signaling
R-HSA-210993: Tie2 Signaling
R-HSA-4420097: VEGFA-VEGFR2 Pathway
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PIK3CA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PIK3CA and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28177435Squamous Cell Lung CarcinomaInhibit immunityAnalysis of mutations with immune markers revealed that ADCY8 and PIK3CA mutations were associated with markedly decreased tumoral PD-L1 expression, LUSCs with PIK3CA mutations exhibited elevated CD45ro levels and CDKN2A-mutant tumors displayed an up-regulated immune response.
27687306Lung adenocarcinomaInhibit immunityTumoral PD-L1 was significantly elevated in TP53 mutant LUADs whereas PIK3CA mutant LUADs exhibited markedly down-regulated PD-L1 expression.
29596783multiple cancer typesInhibit immunityMYC alterations were mutually exclusive with PIK3CA, PTEN, APC, or BRAF alterations, suggesting that MYC is a distinct oncogenic driver.
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PIK3CA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -1.80; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PIK3CA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0190.953
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1250.92
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0520.951
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1730.646
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3720.847
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0820.974
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.120.732
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2010.89
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0360.982
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0620.949
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8780.499
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0340.54
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PIK3CA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.311.82.51
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.418.2-2.81
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.218.83.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472528.6-3.61
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIK3CA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIK3CA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIK3CA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIK3CA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PIK3CA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PIK3CA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Aliases phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ......
Chromosomal Location3q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PIK3CA collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PIK3CA.
ID Name Drug Type Targets #Targets
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB00201CaffeineSmall MoleculeADORA1, ADORA2A, ATM, ITPR1, ITPR2, ITPR3, PDE10A, PDE11A, PDE1A, ......33
DB05241XL765Small MoleculeMTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG5
DB08059(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATESmall MoleculePIK3CA, PIK3CG, PIK3R1, PLK14
DB11772PilaralisibSmall MoleculePIK3CA1
DB12483CopanlisibSmall MoleculePIK3CA, PIK3CD2