Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Interaction with PIK3R2 is required for nuclear localization and export. |
Domain |
PF00454 Phosphatidylinositol 3- and 4-kinase PF00792 Phosphoinositide 3-kinase C2 PF02192 PI3-kinase family PF00794 PI3-kinase family PF00613 Phosphoinositide 3-kinase family |
Function |
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001525 angiogenesis GO:0001935 endothelial cell proliferation GO:0001952 regulation of cell-matrix adhesion GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006898 receptor-mediated endocytosis GO:0006909 phagocytosis GO:0006914 autophagy GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007160 cell-matrix adhesion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008654 phospholipid biosynthetic process GO:0010506 regulation of autophagy GO:0010508 positive regulation of autophagy GO:0010810 regulation of cell-substrate adhesion GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0030100 regulation of endocytosis GO:0030168 platelet activation GO:0030258 lipid modification GO:0031589 cell-substrate adhesion GO:0032147 activation of protein kinase activity GO:0033674 positive regulation of kinase activity GO:0034109 homotypic cell-cell adhesion GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0040016 embryonic cleavage GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0045017 glycerolipid biosynthetic process GO:0045860 positive regulation of protein kinase activity GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048259 regulation of receptor-mediated endocytosis GO:0048514 blood vessel morphogenesis GO:0050673 epithelial cell proliferation GO:0050817 coagulation GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0055074 calcium ion homeostasis GO:0060055 angiogenesis involved in wound healing GO:0060627 regulation of vesicle-mediated transport GO:0070527 platelet aggregation GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072583 clathrin-dependent endocytosis GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:2000369 regulation of clathrin-dependent endocytosis |
Molecular Function |
GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0016307 phosphatidylinositol phosphate kinase activity GO:0035004 phosphatidylinositol 3-kinase activity GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0043560 insulin receptor substrate binding GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity |
Cellular Component |
GO:0005942 phosphatidylinositol 3-kinase complex GO:0019898 extrinsic component of membrane GO:0045171 intercellular bridge GO:0061695 transferase complex, transferring phosphorus-containing groups |
KEGG |
hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04070 Phosphatidylinositol signaling system hsa04071 Sphingolipid signaling pathway hsa04140 Regulation of autophagy hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04210 Apoptosis hsa04360 Axon guidance hsa04370 VEGF signaling pathway hsa04380 Osteoclast differentiation hsa04510 Focal adhesion hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04611 Platelet activation hsa04620 Toll-like receptor signaling pathway hsa04630 Jak-STAT signaling pathway hsa04650 Natural killer cell mediated cytotoxicity hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04666 Fc gamma R-mediated phagocytosis hsa04668 TNF signaling pathway hsa04670 Leukocyte transendothelial migration hsa04722 Neurotrophin signaling pathway hsa04725 Cholinergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04810 Regulation of actin cytoskeleton hsa04910 Insulin signaling pathway hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04917 Prolactin signaling pathway hsa04919 Thyroid hormone signaling pathway hsa04960 Aldosterone-regulated sodium reabsorption hsa04973 Carbohydrate digestion and absorption hsa00562 Inositol phosphate metabolism |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1500931: Cell-Cell communication R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-202424: Downstream TCR signaling R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-180292: GAB1 signalosome R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-373753: Nephrin interactions R-HSA-1483255: PI Metabolism R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-1483257: Phospholipid metabolism R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-8853659: RET signaling R-HSA-912631: Regulation of signaling by CBL R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2029485: Role of phospholipids in phagocytosis R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-1660499: Synthesis of PIPs at the plasma membrane R-HSA-202403: TCR signaling R-HSA-210993: Tie2 Signaling R-HSA-4420097: VEGFA-VEGFR2 Pathway |
Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PIK3CB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PIK3CB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PIK3CB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PIK3CB in various data sets.
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Points in the above scatter plot represent the mutation difference of PIK3CB in various data sets.
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Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIK3CB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIK3CB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIK3CB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIK3CB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PIK3CB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PIK3CB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PIK3CB |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Aliases | PIK3C1; phosphoinositide-3-kinase, catalytic, beta polypeptide; P110BETA; PI3KBETA; PI3-kinase p110 subunit ...... |
Chromosomal Location | 3q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PIK3CB collected from DrugBank database. |
Details on drugs targeting PIK3CB.
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