Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane |
Domain |
PF00454 Phosphatidylinositol 3- and 4-kinase PF00792 Phosphoinositide 3-kinase C2 PF00794 PI3-kinase family PF00613 Phosphoinositide 3-kinase family |
Function |
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. |
Biological Process |
GO:0001525 angiogenesis GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002279 mast cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002407 dendritic cell chemotaxis GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002526 acute inflammatory response GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0002679 respiratory burst involved in defense response GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006887 exocytosis GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006941 striated muscle contraction GO:0006942 regulation of striated muscle contraction GO:0007159 leukocyte cell-cell adhesion GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008654 phospholipid biosynthetic process GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010818 T cell chemotaxis GO:0010896 regulation of triglyceride catabolic process GO:0010897 negative regulation of triglyceride catabolic process GO:0010959 regulation of metal ion transport GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014074 response to purine-containing compound GO:0016042 lipid catabolic process GO:0019216 regulation of lipid metabolic process GO:0019433 triglyceride catabolic process GO:0030168 platelet activation GO:0030258 lipid modification GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032252 secretory granule localization GO:0032418 lysosome localization GO:0032943 mononuclear cell proliferation GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033674 positive regulation of kinase activity GO:0034109 homotypic cell-cell adhesion GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035747 natural killer cell chemotaxis GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0036336 dendritic cell migration GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0043299 leukocyte degranulation GO:0043303 mast cell degranulation GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0044057 regulation of system process GO:0044242 cellular lipid catabolic process GO:0044346 fibroblast apoptotic process GO:0045017 glycerolipid biosynthetic process GO:0045055 regulated exocytosis GO:0045123 cellular extravasation GO:0045576 mast cell activation GO:0045730 respiratory burst GO:0045822 negative regulation of heart contraction GO:0045833 negative regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0045932 negative regulation of muscle contraction GO:0045988 negative regulation of striated muscle contraction GO:0046461 neutral lipid catabolic process GO:0046464 acylglycerol catabolic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046503 glycerolipid catabolic process GO:0046651 lymphocyte proliferation GO:0046683 response to organophosphorus GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048247 lymphocyte chemotaxis GO:0048514 blood vessel morphogenesis GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0050994 regulation of lipid catabolic process GO:0050995 negative regulation of lipid catabolic process GO:0051480 regulation of cytosolic calcium ion concentration GO:0051591 response to cAMP GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051656 establishment of organelle localization GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0051924 regulation of calcium ion transport GO:0055074 calcium ion homeostasis GO:0055117 regulation of cardiac muscle contraction GO:0055118 negative regulation of cardiac muscle contraction GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060326 cell chemotaxis GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070527 platelet aggregation GO:0070588 calcium ion transmembrane transport GO:0070661 leukocyte proliferation GO:0070838 divalent metal ion transport GO:0071320 cellular response to cAMP GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071593 lymphocyte aggregation GO:0071621 granulocyte chemotaxis GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072672 neutrophil extravasation GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090207 regulation of triglyceride metabolic process GO:0090209 negative regulation of triglyceride metabolic process GO:0090257 regulation of muscle system process GO:0097284 hepatocyte apoptotic process GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1903169 regulation of calcium ion transmembrane transport GO:1903522 regulation of blood circulation GO:1903523 negative regulation of blood circulation GO:1904019 epithelial cell apoptotic process GO:1904062 regulation of cation transmembrane transport GO:1990266 neutrophil migration GO:2000269 regulation of fibroblast apoptotic process GO:2000270 negative regulation of fibroblast apoptotic process |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0016307 phosphatidylinositol phosphate kinase activity GO:0035004 phosphatidylinositol 3-kinase activity GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0046875 ephrin receptor binding GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity |
Cellular Component |
GO:0005942 phosphatidylinositol 3-kinase complex GO:0005944 phosphatidylinositol 3-kinase complex, class IB GO:0019898 extrinsic component of membrane GO:0042629 mast cell granule GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0097651 phosphatidylinositol 3-kinase complex, class I |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04611 Platelet activation hsa04725 Cholinergic synapse hsa04921 Oxytocin signaling pathway hsa00562 Inositol phosphate metabolism |
Reactome |
R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-109582: Hemostasis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1483255: PI Metabolism R-HSA-1483257: Phospholipid metabolism R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-1660499: Synthesis of PIPs at the plasma membrane |
Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PIK3CG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PIK3CG and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PIK3CG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PIK3CG in various data sets.
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Points in the above scatter plot represent the mutation difference of PIK3CG in various data sets.
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Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIK3CG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIK3CG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIK3CG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIK3CG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PIK3CG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PIK3CG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PIK3CG |
Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
Aliases | phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ...... |
Chromosomal Location | 7q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PIK3CG collected from DrugBank database. |
Details on drugs targeting PIK3CG.
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