Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 2: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane. |
Domain |
PF00069 Protein kinase domain |
Function |
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030522 intracellular receptor signaling pathway GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0046777 protein autophosphorylation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0070561 vitamin D receptor signaling pathway GO:0071295 cellular response to vitamin GO:0071305 cellular response to vitamin D GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071496 cellular response to external stimulus GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0008134 transcription factor binding GO:0030145 manganese ion binding GO:0043021 ribonucleoprotein complex binding GO:0043024 ribosomal small subunit binding |
Cellular Component | - |
KEGG |
hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PIM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PIM1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PIM1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PIM1 in various data sets.
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There is no record. |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PIM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PIM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PIM1 |
Name | Pim-1 proto-oncogene, serine/threonine kinase |
Aliases | PIM; pim-1 oncogene; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1 ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PIM1 collected from DrugBank database. |
Details on drugs targeting PIM1.
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