Browse PIWIL2

Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Domain PF08699 Argonaute linker 1 domain
PF02170 PAZ domain
PF02171 Piwi domain
Function

Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).

> Gene Ontology
 
Biological Process GO:0000966 RNA 5'-end processing
GO:0006304 DNA modification
GO:0006305 DNA alkylation
GO:0006306 DNA methylation
GO:0006417 regulation of translation
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
GO:0010608 posttranscriptional regulation of gene expression
GO:0016458 gene silencing
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019827 stem cell population maintenance
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030718 germ-line stem cell population maintenance
GO:0031047 gene silencing by RNA
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0032259 methylation
GO:0034248 regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0034587 piRNA metabolic process
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0040020 regulation of meiotic nuclear division
GO:0043046 DNA methylation involved in gamete generation
GO:0043414 macromolecule methylation
GO:0043543 protein acylation
GO:0043966 histone H3 acetylation
GO:0043970 histone H3-K9 acetylation
GO:0044154 histone H3-K14 acetylation
GO:0044728 DNA methylation or demethylation
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045836 positive regulation of meiotic nuclear division
GO:0048232 male gamete generation
GO:0048477 oogenesis
GO:0051321 meiotic cell cycle
GO:0051445 regulation of meiotic cell cycle
GO:0051446 positive regulation of meiotic cell cycle
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0060631 regulation of meiosis I
GO:0060903 positive regulation of meiosis I
GO:0061647 histone H3-K9 modification
GO:0071440 regulation of histone H3-K14 acetylation
GO:0071442 positive regulation of histone H3-K14 acetylation
GO:0090068 positive regulation of cell cycle process
GO:0098727 maintenance of cell number
GO:1901983 regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1903046 meiotic cell cycle process
GO:1905269 positive regulation of chromatin organization
GO:2000241 regulation of reproductive process
GO:2000243 positive regulation of reproductive process
GO:2000615 regulation of histone H3-K9 acetylation
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
Molecular Function GO:0003729 mRNA binding
GO:0034584 piRNA binding
Cellular Component GO:0005844 polysome
GO:0010369 chromocenter
GO:0010370 perinucleolar chromocenter
GO:0033391 chromatoid body
GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043186 P granule
GO:0045495 pole plasm
GO:0060293 germ plasm
GO:0071546 pi-body
GO:0097433 dense body
GO:0098687 chromosomal region
GO:1990923 PET complex
> KEGG and Reactome Pathway
 
KEGG hsa04320 Dorso-ventral axis formation
Reactome R-HSA-74160: Gene Expression
R-HSA-211000: Gene Silencing by RNA
R-HSA-5601884: PIWI-interacting RNA (piRNA) biogenesis
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PIWIL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PIWIL2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PIWIL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.0410.0263
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.7360.159
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1720.898
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5530.35
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8190.423
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1290.897
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4220.413
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2170.767
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0050.985
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PIWIL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.84.110.70.0828
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIWIL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIWIL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIWIL2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIWIL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PIWIL2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PIWIL2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPIWIL2
Namepiwi-like RNA-mediated gene silencing 2
Aliases HILI; FLJ10351; Mili; CT80; Hiwi-like; cancer/testis antigen 80; piwi-like 2 (Drosophila); PIWIL1L; 80kDa PI ......
Chromosomal Location8p24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PIWIL2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.