Summary | |
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Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. |
Domain |
PF02170 PAZ domain PF02171 Piwi domain |
Function |
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). |
Biological Process |
GO:0006417 regulation of translation GO:0007283 spermatogenesis GO:0010608 posttranscriptional regulation of gene expression GO:0016458 gene silencing GO:0031047 gene silencing by RNA GO:0034248 regulation of cellular amide metabolic process GO:0048232 male gamete generation GO:0051321 meiotic cell cycle |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04320 Dorso-ventral axis formation |
Reactome | - |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PIWIL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PIWIL3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PIWIL3 in various data sets.
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Points in the above scatter plot represent the mutation difference of PIWIL3 in various data sets.
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Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIWIL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIWIL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIWIL3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIWIL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PIWIL3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PIWIL3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PIWIL3 |
Name | piwi-like RNA-mediated gene silencing 3 |
Aliases | HIWI3; piwi-like 3 (Drosophila); piwi-like 3; Piwi-like protein 3 |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PIWIL3 collected from DrugBank database. |
There is no record. |