Browse PKD1L2

Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF02140 Galactose binding lectin domain
PF01825 GPCR proteolysis site
PF00059 Lectin C-type domain
PF08016 Polycystin cation channel
PF01477 PLAT/LH2 domain
PF02010 REJ domain
Function

May function as an ion-channel regulator. May function as a G-protein-coupled receptor.

> Gene Ontology
 
Biological Process GO:0006816 calcium ion transport
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009612 response to mechanical stimulus
GO:0050982 detection of mechanical stimulus
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
Molecular Function GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
GO:0030246 carbohydrate binding
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PKD1L2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PKD1L2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PKD1L2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7860.0117
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.1080.0377
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5560.236
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2890.506
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3930.812
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1580.938
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4460.477
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5330.559
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4430.649
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1010.883
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8690.338
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2520.383
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PKD1L2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.111.8-4.71
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031066.7-56.70.108
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.78.2-4.50.671
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.710.2-6.50.425
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.118.8-7.71
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.93.74.20.636
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PKD1L2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PKD1L2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PKD1L2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PKD1L2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PKD1L2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PKD1L2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPKD1L2
Namepolycystic kidney disease 1-like 2 (gene/pseudogene)
Aliases KIAA1879; polycystic kidney disease 1-like 2; PC1L2; PC1-like 2 protein; polycystin-1L2; Polycystic kidney d ......
Chromosomal Location16q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PKD1L2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.