Browse PKD2L1

Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.
Domain PF08016 Polycystin cation channel
Function

Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.

> Gene Ontology
 
Biological Process GO:0001581 detection of chemical stimulus involved in sensory perception of sour taste
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007224 smoothened signaling pathway
GO:0009268 response to pH
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009612 response to mechanical stimulus
GO:0010447 response to acidic pH
GO:0015672 monovalent inorganic cation transport
GO:0035725 sodium ion transmembrane transport
GO:0050907 detection of chemical stimulus involved in sensory perception
GO:0050909 sensory perception of taste
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0050915 sensory perception of sour taste
GO:0050982 detection of mechanical stimulus
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0070206 protein trimerization
GO:0070207 protein homotrimerization
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071214 cellular response to abiotic stimulus
GO:0071467 cellular response to pH
GO:0071468 cellular response to acidic pH
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0072511 divalent inorganic cation transport
Molecular Function GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0008527 taste receptor activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015269 calcium-activated potassium channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022839 ion gated channel activity
GO:0033040 sour taste receptor activity
GO:0042805 actinin binding
GO:0046873 metal ion transmembrane transporter activity
GO:0051371 muscle alpha-actinin binding
GO:0051393 alpha-actinin binding
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0005929 cilium
GO:0031253 cell projection membrane
GO:0031513 nonmotile primary cilium
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0043235 receptor complex
GO:0044441 ciliary part
GO:0060170 ciliary membrane
GO:0072372 primary cilium
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04742 Taste transduction
Reactome -
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PKD2L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PKD2L1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PKD2L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9020.188
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0080.389
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.7680.569
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4290.541
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.2920.202
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5210.628
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.2590.115
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3020.226
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6610.00441
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PKD2L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 1417011.8-11.80.488
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.37.4-2.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.57.15.41
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PKD2L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PKD2L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PKD2L1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PKD2L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PKD2L1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PKD2L1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPKD2L1
Namepolycystic kidney disease 2-like 1
Aliases TRPP3; transient receptor potential cation channel, subfamily P, member 3; PKD2L; PKDL; polycystin-2 homolog ......
Chromosomal Location10q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PKD2L1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.