Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00068 Phospholipase A2 |
Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. |
Biological Process |
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0006575 cellular modified amino acid metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0006658 phosphatidylserine metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016042 lipid catabolic process GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0032309 icosanoid secretion GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0035710 CD4-positive, alpha-beta T cell activation GO:0036148 phosphatidylglycerol acyl-chain remodeling GO:0036149 phosphatidylinositol acyl-chain remodeling GO:0036150 phosphatidylserine acyl-chain remodeling GO:0036151 phosphatidylcholine acyl-chain remodeling GO:0036152 phosphatidylethanolamine acyl-chain remodeling GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0045066 regulatory T cell differentiation GO:0046470 phosphatidylcholine metabolic process GO:0046471 phosphatidylglycerol metabolic process GO:0046473 phosphatidic acid metabolic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0046942 carboxylic acid transport GO:0050482 arachidonic acid secretion GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071715 icosanoid transport GO:0097164 ammonium ion metabolic process GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903963 arachidonate transport |
Molecular Function |
GO:0001948 glycoprotein binding GO:0004620 phospholipase activity GO:0004623 phospholipase A2 activity GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0016298 lipase activity GO:0043394 proteoglycan binding GO:0043395 heparan sulfate proteoglycan binding GO:0052689 carboxylic ester hydrolase activity GO:1901681 sulfur compound binding |
Cellular Component | - |
KEGG |
hsa04014 Ras signaling pathway hsa04270 Vascular smooth muscle contraction hsa04972 Pancreatic secretion hsa04975 Fat digestion and absorption hsa00564 Glycerophospholipid metabolism hsa00565 Ether lipid metabolism hsa00590 Arachidonic acid metabolism hsa00591 Linoleic acid metabolism hsa00592 alpha-Linolenic acid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1482788: Acyl chain remodelling of PC R-HSA-1482839: Acyl chain remodelling of PE R-HSA-1482925: Acyl chain remodelling of PG R-HSA-1482922: Acyl chain remodelling of PI R-HSA-1482801: Acyl chain remodelling of PS R-HSA-1483206: Glycerophospholipid biosynthesis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1483257: Phospholipid metabolism R-HSA-1483166: Synthesis of PA |
Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PLA2G2D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PLA2G2D and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PLA2G2D in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PLA2G2D in various data sets.
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There is no record. |
Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLA2G2D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLA2G2D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLA2G2D. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLA2G2D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PLA2G2D expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PLA2G2D and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PLA2G2D |
Name | phospholipase A2, group IID |
Aliases | sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PLA2G2D collected from DrugBank database. |
Details on drugs targeting PLA2G2D.
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