Summary | |
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Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00068 Phospholipase A2 |
Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. |
Biological Process |
GO:0006575 cellular modified amino acid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0006658 phosphatidylserine metabolic process GO:0006663 platelet activating factor biosynthetic process GO:0006690 icosanoid metabolic process GO:0006691 leukotriene metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0008654 phospholipid biosynthetic process GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010876 lipid localization GO:0014074 response to purine-containing compound GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016042 lipid catabolic process GO:0016053 organic acid biosynthetic process GO:0019370 leukotriene biosynthetic process GO:0032309 icosanoid secretion GO:0033559 unsaturated fatty acid metabolic process GO:0036148 phosphatidylglycerol acyl-chain remodeling GO:0036149 phosphatidylinositol acyl-chain remodeling GO:0036150 phosphatidylserine acyl-chain remodeling GO:0036151 phosphatidylcholine acyl-chain remodeling GO:0036152 phosphatidylethanolamine acyl-chain remodeling GO:0043410 positive regulation of MAPK cascade GO:0044283 small molecule biosynthetic process GO:0045017 glycerolipid biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046469 platelet activating factor metabolic process GO:0046470 phosphatidylcholine metabolic process GO:0046471 phosphatidylglycerol metabolic process GO:0046473 phosphatidic acid metabolic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046683 response to organophosphorus GO:0046942 carboxylic acid transport GO:0050482 arachidonic acid secretion GO:0051591 response to cAMP GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071715 icosanoid transport GO:0072330 monocarboxylic acid biosynthetic process GO:0097164 ammonium ion metabolic process GO:1903963 arachidonate transport |
Molecular Function |
GO:0004620 phospholipase activity GO:0004623 phospholipase A2 activity GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0016298 lipase activity GO:0047498 calcium-dependent phospholipase A2 activity GO:0052689 carboxylic ester hydrolase activity GO:1901681 sulfur compound binding |
Cellular Component | - |
KEGG |
hsa04014 Ras signaling pathway hsa04270 Vascular smooth muscle contraction hsa04972 Pancreatic secretion hsa04975 Fat digestion and absorption hsa00564 Glycerophospholipid metabolism hsa00565 Ether lipid metabolism hsa00590 Arachidonic acid metabolism hsa00591 Linoleic acid metabolism hsa00592 alpha-Linolenic acid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1482788: Acyl chain remodelling of PC R-HSA-1482839: Acyl chain remodelling of PE R-HSA-1482925: Acyl chain remodelling of PG R-HSA-1482922: Acyl chain remodelling of PI R-HSA-1482801: Acyl chain remodelling of PS R-HSA-1483206: Glycerophospholipid biosynthesis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1483257: Phospholipid metabolism R-HSA-1483166: Synthesis of PA |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PLA2G5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PLA2G5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PLA2G5 in various data sets.
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Points in the above scatter plot represent the mutation difference of PLA2G5 in various data sets.
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Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLA2G5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLA2G5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLA2G5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLA2G5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PLA2G5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PLA2G5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PLA2G5 |
Name | phospholipase A2, group V |
Aliases | FRFB; GV-PLA2; PLA2-10; hVPLA(2); Ca2+-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; Gr ...... |
Chromosomal Location | 1p36-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PLA2G5 collected from DrugBank database. |
There is no record. |