Summary | |
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Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Shows weak transcriptional activatory activity. |
Biological Process |
GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0009791 post-embryonic development GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034377 plasma lipoprotein particle assembly GO:0034378 chylomicron assembly GO:0051222 positive regulation of protein transport GO:0065005 protein-lipid complex assembly GO:0070585 protein localization to mitochondrion GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:0097006 regulation of plasma lipoprotein particle levels GO:0097193 intrinsic apoptotic signaling pathway GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PLAGL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PLAGL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PLAGL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PLAGL2 in various data sets.
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Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLAGL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLAGL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLAGL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLAGL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PLAGL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PLAGL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PLAGL2 |
Name | pleiomorphic adenoma gene-like 2 |
Aliases | ZNF900; pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2 |
Chromosomal Location | 20q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PLAGL2 collected from DrugBank database. |
There is no record. |