Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm, perinuclear region Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). |
Domain |
PF00168 C2 domain PF09279 Phosphoinositide-specific phospholipase C PF00388 Phosphatidylinositol-specific phospholipase C PF00387 Phosphatidylinositol-specific phospholipase C |
Function |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006816 calcium ion transport GO:0007338 single fertilization GO:0007343 egg activation GO:0009566 fertilization GO:0016042 lipid catabolic process GO:0019751 polyol metabolic process GO:0043647 inositol phosphate metabolic process GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport GO:1901615 organic hydroxy compound metabolic process |
Molecular Function |
GO:0004435 phosphatidylinositol phospholipase C activity GO:0004620 phospholipase activity GO:0004629 phospholipase C activity GO:0008081 phosphoric diester hydrolase activity GO:0016298 lipase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component | - |
KEGG |
hsa04020 Calcium signaling pathway hsa04070 Phosphatidylinositol signaling system hsa04114 Oocyte meiosis hsa04919 Thyroid hormone signaling pathway hsa00562 Inositol phosphate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1483249: Inositol phosphate metabolism R-HSA-1430728: Metabolism R-HSA-1855204: Synthesis of IP3 and IP4 in the cytosol |
Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PLCZ1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PLCZ1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PLCZ1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PLCZ1 in various data sets.
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Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLCZ1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLCZ1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLCZ1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLCZ1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PLCZ1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PLCZ1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PLCZ1 |
Name | phospholipase C, zeta 1 |
Aliases | NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PLCZ1 collected from DrugBank database. |
There is no record. |