Browse PLCZ1

Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm, perinuclear region Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity).
Domain PF00168 C2 domain
PF09279 Phosphoinositide-specific phospholipase C
PF00388 Phosphatidylinositol-specific phospholipase C
PF00387 Phosphatidylinositol-specific phospholipase C
Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

> Gene Ontology
 
Biological Process GO:0006066 alcohol metabolic process
GO:0006816 calcium ion transport
GO:0007338 single fertilization
GO:0007343 egg activation
GO:0009566 fertilization
GO:0016042 lipid catabolic process
GO:0019751 polyol metabolic process
GO:0043647 inositol phosphate metabolic process
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
GO:1901615 organic hydroxy compound metabolic process
Molecular Function GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004620 phospholipase activity
GO:0004629 phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016298 lipase activity
GO:0042578 phosphoric ester hydrolase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04070 Phosphatidylinositol signaling system
hsa04114 Oocyte meiosis
hsa04919 Thyroid hormone signaling pathway
hsa00562 Inositol phosphate metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1483249: Inositol phosphate metabolism
R-HSA-1430728: Metabolism
R-HSA-1855204: Synthesis of IP3 and IP4 in the cytosol
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PLCZ1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PLCZ1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PLCZ1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.510.385
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2560.834
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8370.532
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0360.873
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PLCZ1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.96.819.10.0153
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.96.819.10.0313
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.2013.20.0705
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLCZ1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLCZ1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLCZ1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLCZ1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PLCZ1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PLCZ1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPLCZ1
Namephospholipase C, zeta 1
Aliases NYD-SP27; PLCzeta; PLC-zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testis-de ......
Chromosomal Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PLCZ1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.