Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Cytoplasm Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. |
Domain |
PF00169 PH domain |
Function |
Required for proper localization of retinogeniculate projections but not for eye-specific segregation. |
Biological Process |
GO:0007602 phototransduction GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus |
Molecular Function |
GO:0008022 protein C-terminus binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PLEKHB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PLEKHB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PLEKHB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PLEKHB1 in various data sets.
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Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLEKHB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLEKHB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLEKHB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLEKHB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PLEKHB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PLEKHB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PLEKHB1 |
Name | pleckstrin homology domain containing, family B (evectins) member 1 |
Aliases | PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ...... |
Chromosomal Location | 11q13.5-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PLEKHB1 collected from DrugBank database. |
There is no record. |