Browse PLEKHB1

Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Cytoplasm Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones.
Domain PF00169 PH domain
Function

Required for proper localization of retinogeniculate projections but not for eye-specific segregation.

> Gene Ontology
 
Biological Process GO:0007602 phototransduction
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009583 detection of light stimulus
Molecular Function GO:0008022 protein C-terminus binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PLEKHB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PLEKHB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PLEKHB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14122.1920.00618
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.4580.515
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)872.7330.0952
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2530.624
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0960.305
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8090.514
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3120.611
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.1640.457
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7880.608
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2130.871
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.6270.73
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4320.0448
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PLEKHB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLEKHB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLEKHB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLEKHB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLEKHB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PLEKHB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PLEKHB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPLEKHB1
Namepleckstrin homology domain containing, family B (evectins) member 1
Aliases PHR1; KPL1; PHRET1; PH domain containing, retinal 1; PH domain containing protein in retina 1; PH domain-con ......
Chromosomal Location11q13.5-q14.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PLEKHB1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.