Browse PMAIP1

Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion
Domain PF15150 Phorbol-12-myristate-13-acetate-induced
Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

> Gene Ontology
 
Biological Process GO:0001666 response to hypoxia
GO:0001776 leukocyte homeostasis
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0002260 lymphocyte homeostasis
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006839 mitochondrial transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006 mitochondrial membrane organization
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0009267 cellular response to starvation
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009615 response to virus
GO:0009991 response to extracellular stimulus
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0010498 proteasomal protein catabolic process
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0019318 hexose metabolic process
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0031334 positive regulation of protein complex assembly
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0032459 regulation of protein oligomerization
GO:0032461 positive regulation of protein oligomerization
GO:0034976 response to endoplasmic reticulum stress
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0042149 cellular response to glucose starvation
GO:0042391 regulation of membrane potential
GO:0042594 response to starvation
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043029 T cell homeostasis
GO:0043254 regulation of protein complex assembly
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043331 response to dsRNA
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044262 cellular carbohydrate metabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045837 negative regulation of membrane potential
GO:0045862 positive regulation of proteolysis
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0048872 homeostasis of number of cells
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051259 protein oligomerization
GO:0051402 neuron apoptotic process
GO:0051607 defense response to virus
GO:0051881 regulation of mitochondrial membrane potential
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070482 response to oxygen levels
GO:0070585 protein localization to mitochondrion
GO:0070997 neuron death
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071496 cellular response to external stimulus
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072593 reactive oxygen species metabolic process
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090199 regulation of release of cytochrome c from mitochondria
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090559 regulation of membrane permeability
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:0098542 defense response to other organism
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2001020 regulation of response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function -
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
> KEGG and Reactome Pathway
 
KEGG hsa04115 p53 signaling pathway
hsa04210 Apoptosis
Reactome R-HSA-114452: Activation of BH3-only proteins
R-HSA-111448: Activation of NOXA and translocation to mitochondria
R-HSA-109581: Apoptosis
R-HSA-111453: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-5357801: Programmed Cell Death
R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes
R-HSA-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PMAIP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PMAIP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.74 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PMAIP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4840.381
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.480.807
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4670.698
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8120.152
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5820.55
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1140.371
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4060.456
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0510.967
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8520.519
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1420.848
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3140.781
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1210.432
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PMAIP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PMAIP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PMAIP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PMAIP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PMAIP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PMAIP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPMAIP1
Namephorbol-12-myristate-13-acetate-induced protein 1
Aliases NOXA; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein ......
Chromosomal Location18q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PMAIP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.