Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes.; SUBCELLULAR LOCATION: M-alpha: Secreted. |
Domain |
PF00801 PKD domain |
Function |
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. |
Biological Process |
GO:0006582 melanin metabolic process GO:0016050 vesicle organization GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0032438 melanosome organization GO:0033059 cellular pigmentation GO:0042438 melanin biosynthetic process GO:0042440 pigment metabolic process GO:0043473 pigmentation GO:0044550 secondary metabolite biosynthetic process GO:0046148 pigment biosynthetic process GO:0046189 phenol-containing compound biosynthetic process GO:0048066 developmental pigmentation GO:0048753 pigment granule organization GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process |
Molecular Function | - |
Cellular Component |
GO:0005770 late endosome GO:0005771 multivesicular body GO:0010008 endosome membrane GO:0031902 late endosome membrane GO:0032585 multivesicular body membrane GO:0042470 melanosome GO:0044440 endosomal part GO:0048770 pigment granule |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PMEL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PMEL and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of PMEL in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PMEL in various data sets.
|
Points in the above scatter plot represent the mutation difference of PMEL in various data sets.
|
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PMEL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PMEL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PMEL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PMEL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PMEL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PMEL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PMEL |
Name | premelanosome protein |
Aliases | D12S53E; Pmel17; gp100; SILV; silver (mouse homolog) like; silver homolog (mouse); ME20; ME20-M; ME20M; P100 ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PMEL collected from DrugBank database. |
There is no record. |