Summary | |
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Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Secreted, extracellular space, extracellular matrix.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm ; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm ; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm |
Domain |
PF13306 Leucine rich repeats (6 copies) PF13855 Leucine rich repeat |
Function |
Negatively regulates cell proliferation and cell migration. |
Biological Process |
GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0007259 JAK-STAT cascade GO:0030336 negative regulation of cell migration GO:0033673 negative regulation of kinase activity GO:0040013 negative regulation of locomotion GO:0042326 negative regulation of phosphorylation GO:0046425 regulation of JAK-STAT cascade GO:0046426 negative regulation of JAK-STAT cascade GO:0051271 negative regulation of cellular component movement GO:0051348 negative regulation of transferase activity GO:0097696 STAT cascade GO:1902532 negative regulation of intracellular signal transduction GO:1904892 regulation of STAT cascade GO:1904893 negative regulation of STAT cascade GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0005518 collagen binding GO:0019207 kinase regulator activity GO:0019210 kinase inhibitor activity GO:0019887 protein kinase regulator activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PODN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PODN in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PODN in various data sets.
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Points in the above scatter plot represent the mutation difference of PODN in various data sets.
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Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PODN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PODN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PODN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PODN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PODN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PODN |
Name | podocan |
Aliases | PCAN; MGC24995; SLRR5A; podocan proteoglycan |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PODN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |