Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage. |
Domain |
PF14792 DNA polymerase beta palm PF14791 DNA polymerase beta thumb PF10391 Fingers domain of DNA polymerase lambda PF14716 Helix-hairpin-helix domain |
Function |
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. |
Biological Process |
GO:0002200 somatic diversification of immune receptors GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002566 somatic diversification of immune receptors via somatic mutation GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006266 DNA ligation GO:0006284 base-excision repair GO:0006286 base-excision repair, base-free sugar-phosphate removal GO:0006287 base-excision repair, gap-filling GO:0006288 base-excision repair, DNA ligation GO:0006290 pyrimidine dimer repair GO:0006310 DNA recombination GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007568 aging GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009314 response to radiation GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0016311 dephosphorylation GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016446 somatic hypermutation of immunoglobulin genes GO:0016447 somatic recombination of immunoglobulin gene segments GO:0022612 gland morphogenesis GO:0033151 V(D)J recombination GO:0033152 immunoglobulin V(D)J recombination GO:0035272 exocrine system development GO:0036296 response to increased oxygen levels GO:0045471 response to ethanol GO:0048535 lymph node development GO:0048536 spleen development GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0051103 DNA ligation involved in DNA repair GO:0051402 neuron apoptotic process GO:0055093 response to hyperoxia GO:0070482 response to oxygen levels GO:0070997 neuron death GO:0071707 immunoglobulin heavy chain V-D-J recombination GO:0071897 DNA biosynthetic process GO:0097193 intrinsic apoptotic signaling pathway GO:0097305 response to alcohol GO:0098501 polynucleotide dephosphorylation GO:0098502 DNA dephosphorylation |
Molecular Function |
GO:0003684 damaged DNA binding GO:0003887 DNA-directed DNA polymerase activity GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0004518 nuclease activity GO:0004519 endonuclease activity GO:0004520 endodeoxyribonuclease activity GO:0004536 deoxyribonuclease activity GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0016779 nucleotidyltransferase activity GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0034061 DNA polymerase activity |
Cellular Component |
GO:0005819 spindle GO:0005874 microtubule GO:0005876 spindle microtubule |
KEGG |
hsa03410 Base excision repair |
Reactome |
R-HSA-5649702: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-73930: Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73884: Base Excision Repair R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-392499: Metabolism of proteins R-HSA-5651801: PCNA-Dependent Long Patch Base Excision Repair R-HSA-110362: POLB-Dependent Long Patch Base Excision Repair R-HSA-597592: Post-translational protein modification R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110381: Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-5689880: Ub-specific processing proteases |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between POLB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of POLB in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of POLB in various data sets.
|
Points in the above scatter plot represent the mutation difference of POLB in various data sets.
|
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of POLB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of POLB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by POLB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of POLB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of POLB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between POLB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | POLB |
Name | polymerase (DNA directed), beta |
Aliases | DNA pol beta; DNA polymerase beta subunit; DNA polymerase beta |
Chromosomal Location | 8p12-p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting POLB collected from DrugBank database. |
Details on drugs targeting POLB.
|