Summary | |
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Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Peripheral membrane protein |
Domain |
PF01731 Arylesterase |
Function |
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. |
Biological Process |
GO:0006979 response to oxidative stress GO:0009636 response to toxic substance GO:0019439 aromatic compound catabolic process |
Molecular Function |
GO:0004064 arylesterase activity GO:0046573 lactonohydrolase activity GO:0052689 carboxylic ester hydrolase activity GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity |
Cellular Component | - |
KEGG |
hsa01100 Metabolic pathways |
Reactome |
R-HSA-2142753: Arachidonic acid metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-2142688: Synthesis of 5-eicosatetraenoic acids |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PON2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PON2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PON2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PON2 in various data sets.
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Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PON2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PON2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PON2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PON2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PON2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PON2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PON2 |
Name | paraoxonase 2 |
Aliases | paraoxonase nirs; arylesterase 2; A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PON2 collected from DrugBank database. |
There is no record. |