Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein |
Domain |
PF03062 MBOAT |
Function |
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. |
Biological Process |
GO:0006497 protein lipidation GO:0009100 glycoprotein metabolic process GO:0016055 Wnt signaling pathway GO:0042157 lipoprotein metabolic process GO:0042158 lipoprotein biosynthetic process GO:0043543 protein acylation GO:0045234 protein palmitoleylation GO:0060070 canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt |
Molecular Function |
GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0017147 Wnt-protein binding GO:1990698 palmitoleoyltransferase activity |
Cellular Component |
GO:0008328 ionotropic glutamate receptor complex GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0032281 AMPA glutamate receptor complex GO:0034702 ion channel complex GO:0043235 receptor complex GO:0098802 plasma membrane receptor complex GO:0098878 neurotransmitter receptor complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa04310 Wnt signaling pathway |
Reactome |
R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-162582: Signal Transduction R-HSA-4791275: Signaling by WNT in cancer R-HSA-195721: Signaling by Wnt R-HSA-3238698: WNT ligand biogenesis and trafficking R-HSA-5340573: WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 |
Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PORCN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PORCN and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PORCN in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PORCN in various data sets.
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Points in the above scatter plot represent the mutation difference of PORCN in various data sets.
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Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PORCN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PORCN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PORCN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PORCN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PORCN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PORCN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PORCN |
Name | porcupine homolog (Drosophila) |
Aliases | MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ...... |
Chromosomal Location | Xp11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PORCN collected from DrugBank database. |
There is no record. |