Browse PORCN

Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Multi-pass membrane protein
Domain PF03062 MBOAT
Function

Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.

> Gene Ontology
 
Biological Process GO:0006497 protein lipidation
GO:0009100 glycoprotein metabolic process
GO:0016055 Wnt signaling pathway
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0043543 protein acylation
GO:0045234 protein palmitoleylation
GO:0060070 canonical Wnt signaling pathway
GO:0198738 cell-cell signaling by wnt
Molecular Function GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0017147 Wnt-protein binding
GO:1990698 palmitoleoyltransferase activity
Cellular Component GO:0008328 ionotropic glutamate receptor complex
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0032281 AMPA glutamate receptor complex
GO:0034702 ion channel complex
GO:0043235 receptor complex
GO:0098802 plasma membrane receptor complex
GO:0098878 neurotransmitter receptor complex
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04310 Wnt signaling pathway
Reactome R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-162582: Signal Transduction
R-HSA-4791275: Signaling by WNT in cancer
R-HSA-195721: Signaling by Wnt
R-HSA-3238698: WNT ligand biogenesis and trafficking
R-HSA-5340573: WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PORCN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PORCN and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26041736MelanomaInhibit immunity (T cell function)We further show that the genetic silencing of the PORCN membrane-bound O-acyl transferase, which is necessary for melanoma Wnt ligand secretion, enhances antitumor T-cell immunity, and that the pharmacologic inhibition of this enzyme synergistically suppresses melanoma progression when combined with anti-CTLA-4 antibody therapy.
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PORCN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PORCN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0960.689
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3310.816
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4020.676
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1520.624
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0670.963
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4290.811
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1260.686
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1510.856
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1110.901
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1910.273
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.7160.267
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2860.00643
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PORCN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PORCN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PORCN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PORCN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PORCN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PORCN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PORCN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPORCN
Nameporcupine homolog (Drosophila)
Aliases MG61; PPN; DHOF; dermal hypoplasia, focal; FODH; probable protein-cysteine N-palmitoyltransferase porcupine; ......
Chromosomal LocationXp11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PORCN collected from DrugBank database.
> Drugs from DrugBank database
 

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