Summary | |
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Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00046 Homeobox domain PF00157 Pou domain - N-terminal to homeobox domain |
Function |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
Biological Process |
GO:0009301 snRNA transcription GO:0016073 snRNA metabolic process GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0098781 ncRNA transcription |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-74160: Gene Expression R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-749476: RNA Polymerase III Abortive And Retractive Initiation R-HSA-74158: RNA Polymerase III Transcription R-HSA-76046: RNA Polymerase III Transcription Initiation R-HSA-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-6807505: RNA polymerase II transcribes snRNA genes R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between POU2F1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of POU2F1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of POU2F1 in various data sets.
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Points in the above scatter plot represent the mutation difference of POU2F1 in various data sets.
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Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of POU2F1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of POU2F1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by POU2F1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of POU2F1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of POU2F1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between POU2F1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | POU2F1 |
Name | POU class 2 homeobox 1 |
Aliases | OTF1; POU domain class 2, transcription factor 1; oct-1B; NF-A1; OTF-1; Octamer-binding transcription factor ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting POU2F1 collected from DrugBank database. |
There is no record. |