Summary | |
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Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm |
Domain |
PF00046 Homeobox domain PF00157 Pou domain - N-terminal to homeobox domain |
Function |
Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. ; FUNCTION: Isoform 2: Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells. |
Biological Process |
GO:0001708 cell fate specification GO:0001967 suckling behavior GO:0003007 heart morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003223 ventricular compact myocardium morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0006354 DNA-templated transcription, elongation GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006362 transcription elongation from RNA polymerase I promoter GO:0007050 cell cycle arrest GO:0007409 axonogenesis GO:0007416 synapse assembly GO:0007422 peripheral nervous system development GO:0007498 mesoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007631 feeding behavior GO:0014706 striated muscle tissue development GO:0016479 negative regulation of transcription from RNA polymerase I promoter GO:0019230 proprioception GO:0021535 cell migration in hindbrain GO:0021536 diencephalon development GO:0021538 epithalamus development GO:0021545 cranial nerve development GO:0021559 trigeminal nerve development GO:0021675 nerve development GO:0021953 central nervous system neuron differentiation GO:0021986 habenula development GO:0030900 forebrain development GO:0030902 hindbrain development GO:0032784 regulation of DNA-templated transcription, elongation GO:0032785 negative regulation of DNA-templated transcription, elongation GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0045165 cell fate commitment GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0048644 muscle organ morphogenesis GO:0048663 neuron fate commitment GO:0048665 neuron fate specification GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048738 cardiac muscle tissue development GO:0048880 sensory system development GO:0048934 peripheral nervous system neuron differentiation GO:0048935 peripheral nervous system neuron development GO:0050808 synapse organization GO:0050884 neuromuscular process controlling posture GO:0050885 neuromuscular process controlling balance GO:0050905 neuromuscular process GO:0050957 equilibrioception GO:0051355 proprioception involved in equilibrioception GO:0051402 neuron apoptotic process GO:0051705 multi-organism behavior GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060384 innervation GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0061564 axon development GO:0070997 neuron death GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0072331 signal transduction by p53 class mediator GO:0090068 positive regulation of cell cycle process GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901796 regulation of signal transduction by p53 class mediator GO:2001207 regulation of transcription elongation from RNA polymerase I promoter GO:2001208 negative regulation of transcription elongation from RNA polymerase I promoter |
Molecular Function |
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001158 enhancer sequence-specific DNA binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003697 single-stranded DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0035326 enhancer binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between POU4F1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of POU4F1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of POU4F1 in various data sets.
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Points in the above scatter plot represent the mutation difference of POU4F1 in various data sets.
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Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of POU4F1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of POU4F1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by POU4F1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of POU4F1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of POU4F1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between POU4F1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | POU4F1 |
Name | POU class 4 homeobox 1 |
Aliases | BRN3A; POU domain class 4, transcription factor 1; Oct-T1; brn-3A; brain-3A; brain-specific homeobox/POU dom ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting POU4F1 collected from DrugBank database. |
There is no record. |