Summary | |
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Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. |
Domain |
PF00046 Homeobox domain PF00157 Pou domain - N-terminal to homeobox domain |
Function |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
Biological Process |
GO:0001701 in utero embryonic development GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0001708 cell fate specification GO:0001711 endodermal cell fate commitment GO:0001714 endodermal cell fate specification GO:0001824 blastocyst development GO:0006417 regulation of translation GO:0007369 gastrulation GO:0007492 endoderm development GO:0008356 asymmetric cell division GO:0009299 mRNA transcription GO:0009786 regulation of asymmetric cell division GO:0010608 posttranscriptional regulation of gene expression GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017148 negative regulation of translation GO:0019827 stem cell population maintenance GO:0031047 gene silencing by RNA GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0035019 somatic stem cell population maintenance GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035987 endodermal cell differentiation GO:0040029 regulation of gene expression, epigenetic GO:0042789 mRNA transcription from RNA polymerase II promoter GO:0045165 cell fate commitment GO:0045727 positive regulation of translation GO:0051302 regulation of cell division GO:0060147 regulation of posttranscriptional gene silencing GO:0060149 negative regulation of posttranscriptional gene silencing GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0060964 regulation of gene silencing by miRNA GO:0060965 negative regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060967 negative regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:0098727 maintenance of cell number |
Molecular Function |
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0031625 ubiquitin protein ligase binding GO:0035198 miRNA binding GO:0044389 ubiquitin-like protein ligase binding |
Cellular Component | - |
KEGG |
hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-2892247: POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892245: POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-452723: Transcriptional regulation of pluripotent stem cells |
Summary | |
---|---|
Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between POU5F1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between POU5F1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of POU5F1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of POU5F1 in various data sets.
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Points in the above scatter plot represent the mutation difference of POU5F1 in various data sets.
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Summary | |
---|---|
Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of POU5F1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of POU5F1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by POU5F1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of POU5F1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of POU5F1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between POU5F1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | POU5F1 |
Name | POU class 5 homeobox 1 |
Aliases | Oct4; MGC22487; OTF3; POU domain class 5, transcription factor 1; OTF-3; OTF4; Oct-3; Oct-4; POU class 5 hom ...... |
Chromosomal Location | 6p21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting POU5F1 collected from DrugBank database. |
There is no record. |