Summary | |
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Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF00719 Inorganic pyrophosphatase |
Function |
Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). |
Biological Process |
GO:0006399 tRNA metabolic process GO:0006418 tRNA aminoacylation for protein translation GO:0006470 protein dephosphorylation GO:0006520 cellular amino acid metabolic process GO:0016311 dephosphorylation GO:0043038 amino acid activation GO:0043039 tRNA aminoacylation GO:0071344 diphosphate metabolic process |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004427 inorganic diphosphatase activity GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00190 Oxidative phosphorylation |
Reactome |
R-HSA-74160: Gene Expression R-HSA-1430728: Metabolism R-HSA-379726: Mitochondrial tRNA aminoacylation R-HSA-71737: Pyrophosphate hydrolysis R-HSA-379724: tRNA Aminoacylation |
Summary | |
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Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PPA2 in various data sets.
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Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PPA2 |
Name | pyrophosphatase (inorganic) 2 |
Aliases | FLJ20459; HSPC124; SID6-306; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2; Inorganic ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPA2 collected from DrugBank database. |
There is no record. |