Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation. |
Domain |
PF00104 Ligand-binding domain of nuclear hormone receptor PF12577 PPAR gamma N-terminal region PF00105 Zinc finger |
Function |
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). ; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. |
Biological Process |
GO:0001101 response to acid chemical GO:0001558 regulation of cell growth GO:0001890 placenta development GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002521 leukocyte differentiation GO:0002526 acute inflammatory response GO:0002573 myeloid leukocyte differentiation GO:0002673 regulation of acute inflammatory response GO:0002674 negative regulation of acute inflammatory response GO:0002683 negative regulation of immune system process GO:0003013 circulatory system process GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006631 fatty acid metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007507 heart development GO:0007584 response to nutrient GO:0007623 circadian rhythm GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009266 response to temperature stimulus GO:0009409 response to cold GO:0009612 response to mechanical stimulus GO:0009755 hormone-mediated signaling pathway GO:0009991 response to extracellular stimulus GO:0010001 glial cell differentiation GO:0010324 membrane invagination GO:0010565 regulation of cellular ketone metabolic process GO:0010712 regulation of collagen metabolic process GO:0010713 negative regulation of collagen metabolic process GO:0010720 positive regulation of cell development GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010745 negative regulation of macrophage derived foam cell differentiation GO:0010869 regulation of receptor biosynthetic process GO:0010871 negative regulation of receptor biosynthetic process GO:0010876 lipid localization GO:0010878 cholesterol storage GO:0010883 regulation of lipid storage GO:0010885 regulation of cholesterol storage GO:0010887 negative regulation of cholesterol storage GO:0010888 negative regulation of lipid storage GO:0010889 regulation of sequestering of triglyceride GO:0010891 negative regulation of sequestering of triglyceride GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014074 response to purine-containing compound GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015850 organic hydroxy compound transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0015918 sterol transport GO:0016049 cell growth GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019395 fatty acid oxidation GO:0019915 lipid storage GO:0021700 developmental maturation GO:0030099 myeloid cell differentiation GO:0030100 regulation of endocytosis GO:0030224 monocyte differentiation GO:0030258 lipid modification GO:0030301 cholesterol transport GO:0030308 negative regulation of cell growth GO:0030522 intracellular receptor signaling pathway GO:0030730 sequestering of triglyceride GO:0031000 response to caffeine GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031348 negative regulation of defense response GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0032102 negative regulation of response to external stimulus GO:0032368 regulation of lipid transport GO:0032371 regulation of sterol transport GO:0032374 regulation of cholesterol transport GO:0032409 regulation of transporter activity GO:0032526 response to retinoic acid GO:0032799 low-density lipoprotein receptor particle metabolic process GO:0032800 receptor biosynthetic process GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032966 negative regulation of collagen biosynthetic process GO:0033002 muscle cell proliferation GO:0033189 response to vitamin A GO:0033197 response to vitamin E GO:0033273 response to vitamin GO:0033500 carbohydrate homeostasis GO:0034341 response to interferon-gamma GO:0034440 lipid oxidation GO:0034694 response to prostaglandin GO:0034695 response to prostaglandin E GO:0035357 peroxisome proliferator activated receptor signaling pathway GO:0035902 response to immobilization stress GO:0036295 cellular response to increased oxygen levels GO:0036296 response to increased oxygen levels GO:0042063 gliogenesis GO:0042180 cellular ketone metabolic process GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042594 response to starvation GO:0042752 regulation of circadian rhythm GO:0042953 lipoprotein transport GO:0043112 receptor metabolic process GO:0043279 response to alkaloid GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043401 steroid hormone mediated signaling pathway GO:0043434 response to peptide hormone GO:0043627 response to estrogen GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044252 negative regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044872 lipoprotein localization GO:0045088 regulation of innate immune response GO:0045165 cell fate commitment GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045713 low-density lipoprotein particle receptor biosynthetic process GO:0045807 positive regulation of endocytosis GO:0045824 negative regulation of innate immune response GO:0045834 positive regulation of lipid metabolic process GO:0045862 positive regulation of proteolysis GO:0045923 positive regulation of fatty acid metabolic process GO:0045926 negative regulation of growth GO:0046320 regulation of fatty acid oxidation GO:0046321 positive regulation of fatty acid oxidation GO:0046942 carboxylic acid transport GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048147 negative regulation of fibroblast proliferation GO:0048469 cell maturation GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048608 reproductive structure development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0048709 oligodendrocyte differentiation GO:0048713 regulation of oligodendrocyte differentiation GO:0048714 positive regulation of oligodendrocyte differentiation GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050769 positive regulation of neurogenesis GO:0050777 negative regulation of immune response GO:0050872 white fat cell differentiation GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051235 maintenance of location GO:0051348 negative regulation of transferase activity GO:0051962 positive regulation of nervous system development GO:0051972 regulation of telomerase activity GO:0051974 negative regulation of telomerase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055088 lipid homeostasis GO:0055093 response to hyperoxia GO:0055094 response to lipoprotein particle GO:0055098 response to low-density lipoprotein particle GO:0060099 regulation of phagocytosis, engulfment GO:0060100 positive regulation of phagocytosis, engulfment GO:0060330 regulation of response to interferon-gamma GO:0060331 negative regulation of response to interferon-gamma GO:0060333 interferon-gamma-mediated signaling pathway GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway GO:0060627 regulation of vesicle-mediated transport GO:0060694 regulation of cholesterol transporter activity GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0060850 regulation of transcription involved in cell fate commitment GO:0061458 reproductive system development GO:0070482 response to oxygen levels GO:0071229 cellular response to acid chemical GO:0071295 cellular response to vitamin GO:0071300 cellular response to retinoic acid GO:0071306 cellular response to vitamin E GO:0071346 cellular response to interferon-gamma GO:0071375 cellular response to peptide hormone stimulus GO:0071379 cellular response to prostaglandin stimulus GO:0071380 cellular response to prostaglandin E stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071455 cellular response to hyperoxia GO:0071496 cellular response to external stimulus GO:0071897 DNA biosynthetic process GO:0072343 pancreatic stellate cell proliferation GO:0090077 foam cell differentiation GO:0099024 plasma membrane invagination GO:1901558 response to metformin GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1903131 mononuclear cell differentiation GO:1905153 regulation of membrane invagination GO:1905155 positive regulation of membrane invagination GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000229 regulation of pancreatic stellate cell proliferation GO:2000230 negative regulation of pancreatic stellate cell proliferation GO:2000278 regulation of DNA biosynthetic process GO:2000279 negative regulation of DNA biosynthetic process GO:2001056 positive regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0003682 chromatin binding GO:0003707 steroid hormone receptor activity GO:0003713 transcription coactivator activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004953 icosanoid receptor activity GO:0004954 prostanoid receptor activity GO:0004955 prostaglandin receptor activity GO:0005504 fatty acid binding GO:0008134 transcription factor binding GO:0008144 drug binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0030331 estrogen receptor binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0031406 carboxylic acid binding GO:0033293 monocarboxylic acid binding GO:0033613 activating transcription factor binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0036041 long-chain fatty acid binding GO:0042805 actinin binding GO:0042974 retinoic acid receptor binding GO:0043168 anion binding GO:0046965 retinoid X receptor binding GO:0050542 icosanoid binding GO:0050543 icosatetraenoic acid binding GO:0050544 arachidonic acid binding GO:0051393 alpha-actinin binding GO:0051427 hormone receptor binding GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa03320 PPAR signaling pathway hsa04152 AMPK signaling pathway hsa04380 Osteoclast differentiation |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-383280: Nuclear Receptor transcription pathway R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPARG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PPARG and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPARG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPARG in various data sets.
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Points in the above scatter plot represent the mutation difference of PPARG in various data sets.
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Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPARG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPARG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPARG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPARG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPARG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPARG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPARG |
Name | peroxisome proliferator-activated receptor gamma |
Aliases | PPARG1; PPARG2; NR1C3; PPARgamma; peroxisome proliferative activated receptor, gamma; CIMT1; GLM1; NR1C31; P ...... |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPARG collected from DrugBank database. |
Details on drugs targeting PPARG.
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