Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Nucleus. Nucleus, PML body.; SUBCELLULAR LOCATION: Isoform B4: Nucleus.; SUBCELLULAR LOCATION: Isoform B4-8a: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform B5: Nucleus. Nucleus, PML body.; SUBCELLULAR LOCATION: Isoform 9: Nucleus |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM |
Function |
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. |
Biological Process |
GO:0000002 mitochondrial genome maintenance GO:0000266 mitochondrial fission GO:0000302 response to reactive oxygen species GO:0000422 mitophagy GO:0001101 response to acid chemical GO:0001659 temperature homeostasis GO:0001666 response to hypoxia GO:0001678 cellular glucose homeostasis GO:0001933 negative regulation of protein phosphorylation GO:0002021 response to dietary excess GO:0002237 response to molecule of bacterial origin GO:0002931 response to ischemia GO:0003012 muscle system process GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006012 galactose metabolic process GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0006109 regulation of carbohydrate metabolic process GO:0006110 regulation of glycolytic process GO:0006111 regulation of gluconeogenesis GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006397 mRNA processing GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006631 fatty acid metabolic process GO:0006694 steroid biosynthetic process GO:0006700 C21-steroid hormone biosynthetic process GO:0006701 progesterone biosynthetic process GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006754 ATP biosynthetic process GO:0006757 ATP generation from ADP GO:0006914 autophagy GO:0006979 response to oxidative stress GO:0007215 glutamate receptor signaling pathway GO:0007568 aging GO:0007586 digestion GO:0007623 circadian rhythm GO:0008202 steroid metabolic process GO:0008207 C21-steroid hormone metabolic process GO:0008209 androgen metabolic process GO:0008380 RNA splicing GO:0009116 nucleoside metabolic process GO:0009118 regulation of nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009124 nucleoside monophosphate biosynthetic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009127 purine nucleoside monophosphate biosynthetic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009145 purine nucleoside triphosphate biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009156 ribonucleoside monophosphate biosynthetic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009168 purine ribonucleoside monophosphate biosynthetic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009206 purine ribonucleoside triphosphate biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009266 response to temperature stimulus GO:0009409 response to cold GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009750 response to fructose GO:0009755 hormone-mediated signaling pathway GO:0009812 flavonoid metabolic process GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010469 regulation of receptor activity GO:0010565 regulation of cellular ketone metabolic process GO:0010566 regulation of ketone biosynthetic process GO:0010639 negative regulation of organelle organization GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010677 negative regulation of cellular carbohydrate metabolic process GO:0010817 regulation of hormone levels GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0010823 negative regulation of mitochondrion organization GO:0010893 positive regulation of steroid biosynthetic process GO:0010906 regulation of glucose metabolic process GO:0010907 positive regulation of glucose metabolic process GO:0014074 response to purine-containing compound GO:0014732 skeletal muscle atrophy GO:0014812 muscle cell migration GO:0014823 response to activity GO:0014850 response to muscle activity GO:0014874 response to stimulus involved in regulation of muscle adaptation GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation GO:0014888 striated muscle adaptation GO:0014889 muscle atrophy GO:0014891 striated muscle atrophy GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014912 negative regulation of smooth muscle cell migration GO:0015980 energy derivation by oxidation of organic compounds GO:0016051 carbohydrate biosynthetic process GO:0016052 carbohydrate catabolic process GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019218 regulation of steroid metabolic process GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0019362 pyridine nucleotide metabolic process GO:0019395 fatty acid oxidation GO:0021549 cerebellum development GO:0022037 metencephalon development GO:0022898 regulation of transmembrane transporter activity GO:0022900 electron transport chain GO:0022904 respiratory electron transport chain GO:0030258 lipid modification GO:0030336 negative regulation of cell migration GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031000 response to caffeine GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031647 regulation of protein stability GO:0031667 response to nutrient levels GO:0032042 mitochondrial DNA metabolic process GO:0032350 regulation of hormone metabolic process GO:0032352 positive regulation of hormone metabolic process GO:0032354 response to follicle-stimulating hormone GO:0032355 response to estradiol GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032496 response to lipopolysaccharide GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032922 circadian regulation of gene expression GO:0033002 muscle cell proliferation GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0034440 lipid oxidation GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034698 response to gonadotropin GO:0034754 cellular hormone metabolic process GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035634 response to stilbenoid GO:0035864 response to potassium ion GO:0035865 cellular response to potassium ion GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040013 negative regulation of locomotion GO:0042180 cellular ketone metabolic process GO:0042181 ketone biosynthetic process GO:0042278 purine nucleoside metabolic process GO:0042326 negative regulation of phosphorylation GO:0042440 pigment metabolic process GO:0042445 hormone metabolic process GO:0042446 hormone biosynthetic process GO:0042448 progesterone metabolic process GO:0042451 purine nucleoside biosynthetic process GO:0042455 ribonucleoside biosynthetic process GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042594 response to starvation GO:0042752 regulation of circadian rhythm GO:0043200 response to amino acid GO:0043201 response to leucine GO:0043255 regulation of carbohydrate biosynthetic process GO:0043279 response to alkaloid GO:0043401 steroid hormone mediated signaling pathway GO:0043457 regulation of cellular respiration GO:0043467 regulation of generation of precursor metabolites and energy GO:0043470 regulation of carbohydrate catabolic process GO:0043500 muscle adaptation GO:0043501 skeletal muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043543 protein acylation GO:0044057 regulation of system process GO:0044236 multicellular organism metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045333 cellular respiration GO:0045444 fat cell differentiation GO:0045472 response to ether GO:0045722 positive regulation of gluconeogenesis GO:0045820 negative regulation of glycolytic process GO:0045834 positive regulation of lipid metabolic process GO:0045912 negative regulation of carbohydrate metabolic process GO:0045913 positive regulation of carbohydrate metabolic process GO:0045923 positive regulation of fatty acid metabolic process GO:0045940 positive regulation of steroid metabolic process GO:0045978 negative regulation of nucleoside metabolic process GO:0045979 positive regulation of nucleoside metabolic process GO:0045980 negative regulation of nucleotide metabolic process GO:0045981 positive regulation of nucleotide metabolic process GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046129 purine ribonucleoside biosynthetic process GO:0046320 regulation of fatty acid oxidation GO:0046321 positive regulation of fatty acid oxidation GO:0046364 monosaccharide biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046496 nicotinamide nucleotide metabolic process GO:0046885 regulation of hormone biosynthetic process GO:0046886 positive regulation of hormone biosynthetic process GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0046939 nucleotide phosphorylation GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0048871 multicellular organismal homeostasis GO:0050810 regulation of steroid biosynthetic process GO:0050821 protein stabilization GO:0050873 brown fat cell differentiation GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051186 cofactor metabolic process GO:0051193 regulation of cofactor metabolic process GO:0051195 negative regulation of cofactor metabolic process GO:0051196 regulation of coenzyme metabolic process GO:0051198 negative regulation of coenzyme metabolic process GO:0051271 negative regulation of cellular component movement GO:0051402 neuron apoptotic process GO:0051552 flavone metabolic process GO:0051602 response to electrical stimulus GO:0060537 muscle tissue development GO:0060612 adipose tissue development GO:0061448 connective tissue development GO:0061726 mitochondrion disassembly GO:0070482 response to oxygen levels GO:0070542 response to fatty acid GO:0070741 response to interleukin-6 GO:0070997 neuron death GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071229 cellular response to acid chemical GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071250 cellular response to nitrite GO:0071312 cellular response to alkaloid GO:0071313 cellular response to caffeine GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071332 cellular response to fructose stimulus GO:0071333 cellular response to glucose stimulus GO:0071354 cellular response to interleukin-6 GO:0071356 cellular response to tumor necrosis factor GO:0071362 cellular response to ether GO:0071371 cellular response to gonadotropin stimulus GO:0071372 cellular response to follicle-stimulating hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071398 cellular response to fatty acid GO:0071407 cellular response to organic cyclic compound GO:0071415 cellular response to purine-containing compound GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071867 response to monoamine GO:0071869 response to catecholamine GO:0071871 response to epinephrine GO:0071873 response to norepinephrine GO:0072522 purine-containing compound biosynthetic process GO:0072524 pyridine-containing compound metabolic process GO:0080033 response to nitrite GO:0090140 regulation of mitochondrial fission GO:0090257 regulation of muscle system process GO:0090258 negative regulation of mitochondrial fission GO:0097009 energy homeostasis GO:0097066 response to thyroid hormone GO:0097067 cellular response to thyroid hormone stimulus GO:0099601 regulation of neurotransmitter receptor activity GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900449 regulation of glutamate receptor signaling pathway GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901293 nucleoside phosphate biosynthetic process GO:1901558 response to metformin GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process GO:1901857 positive regulation of cellular respiration GO:1901858 regulation of mitochondrial DNA metabolic process GO:1901860 positive regulation of mitochondrial DNA metabolic process GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902170 cellular response to reactive nitrogen species GO:1902275 regulation of chromatin organization GO:1903008 organelle disassembly GO:1903210 glomerular visceral epithelial cell apoptotic process GO:1903578 regulation of ATP metabolic process GO:1903579 negative regulation of ATP metabolic process GO:1903580 positive regulation of ATP metabolic process GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904037 positive regulation of epithelial cell apoptotic process GO:1904633 regulation of glomerular visceral epithelial cell apoptotic process GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process GO:1904636 response to ionomycin GO:1904637 cellular response to ionomycin GO:1904638 response to resveratrol GO:1904639 cellular response to resveratrol GO:1904640 response to methionine GO:1905269 positive regulation of chromatin organization GO:1990845 adaptive thermogenesis GO:2000146 negative regulation of cell motility GO:2000182 regulation of progesterone biosynthetic process GO:2000184 positive regulation of progesterone biosynthetic process GO:2000272 negative regulation of receptor activity GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000505 regulation of energy homeostasis GO:2000507 positive regulation of energy homeostasis GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation GO:2001169 regulation of ATP biosynthetic process GO:2001171 positive regulation of ATP biosynthetic process |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0015631 tubulin binding GO:0016922 ligand-dependent nuclear receptor binding GO:0030331 estrogen receptor binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0031490 chromatin DNA binding GO:0031625 ubiquitin protein ligase binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042975 peroxisome proliferator activated receptor binding GO:0043014 alpha-tubulin binding GO:0043566 structure-specific DNA binding GO:0044389 ubiquitin-like protein ligase binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding GO:1990841 promoter-specific chromatin binding |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0005665 DNA-directed RNA polymerase II, core complex GO:0005719 nuclear euchromatin GO:0005840 ribosome GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0016604 nuclear body GO:0016605 PML body GO:0022626 cytosolic ribosome GO:0030425 dendrite GO:0030880 RNA polymerase complex GO:0043025 neuronal cell body GO:0044297 cell body GO:0044445 cytosolic part GO:0044454 nuclear chromosome part GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0097440 apical dendrite GO:1990843 subsarcolemmal mitochondrion GO:1990844 interfibrillar mitochondrion |
KEGG |
hsa04152 AMPK signaling pathway hsa04910 Insulin signaling pathway hsa04920 Adipocytokine signaling pathway hsa04922 Glucagon signaling pathway |
Reactome |
R-HSA-2151209: Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-1368108: BMAL1 R-HSA-400253: Circadian Clock R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-1368082: RORA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPARGC1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPARGC1A in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPARGC1A in various data sets.
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Points in the above scatter plot represent the mutation difference of PPARGC1A in various data sets.
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Summary | |
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Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPARGC1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPARGC1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPARGC1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPARGC1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPARGC1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPARGC1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PPARGC1A |
Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
Aliases | PGC1; PGC1A; PPARGC1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome prolifer ...... |
Chromosomal Location | 4p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPARGC1A collected from DrugBank database. |
There is no record. |