Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002283 neutrophil activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002446 neutrophil mediated immunity GO:0002523 leukocyte migration involved in inflammatory response GO:0002576 platelet degranulation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006887 exocytosis GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0032103 positive regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0034219 carbohydrate transmembrane transport GO:0035428 hexose transmembrane transport GO:0036230 granulocyte activation GO:0040017 positive regulation of locomotion GO:0042119 neutrophil activation GO:0042742 defense response to bacterium GO:0043299 leukocyte degranulation GO:0043312 neutrophil degranulation GO:0045055 regulated exocytosis GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0051302 regulation of cell division GO:0051781 positive regulation of cell division GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0071621 granulocyte chemotaxis GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:0098542 defense response to other organism GO:1904659 glucose transmembrane transport GO:1990266 neutrophil migration GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005355 glucose transmembrane transporter activity GO:0008009 chemokine activity GO:0008083 growth factor activity GO:0015144 carbohydrate transmembrane transporter activity GO:0015145 monosaccharide transmembrane transporter activity GO:0015149 hexose transmembrane transporter activity GO:0042379 chemokine receptor binding GO:0045236 CXCR chemokine receptor binding GO:0051119 sugar transmembrane transporter activity GO:1901476 carbohydrate transporter activity |
Cellular Component |
GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-375276: Peptide ligand-binding receptors R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPBP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPBP in various data sets.
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Points in the above scatter plot represent the mutation difference of PPBP in various data sets.
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Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPBP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPBP |
Name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
Aliases | SCYB7; TGB; NAP-2-L1; LA-PF4; MDGF; LDGF; Beta-TG; CTAP3; CXCL7; b-TG1; TGB1; CTAPIII; platelet basic protei ...... |
Chromosomal Location | 4q12-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPBP collected from DrugBank database. |
Details on drugs targeting PPBP.
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