Summary | |
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Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). |
Biological Process |
GO:0000413 protein peptidyl-prolyl isomerization GO:0006457 protein folding GO:0018208 peptidyl-proline modification |
Molecular Function |
GO:0003755 peptidyl-prolyl cis-trans isomerase activity GO:0016853 isomerase activity GO:0016859 cis-trans isomerase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPIAL4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPIAL4A in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPIAL4A in various data sets.
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Points in the above scatter plot represent the mutation difference of PPIAL4A in various data sets.
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Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPIAL4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPIAL4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPIAL4A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPIAL4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPIAL4A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPIAL4A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PPIAL4A |
Name | peptidylprolyl isomerase A (cyclophilin A)-like 4A |
Aliases | PPIAL4; PPIAL4B; peptidylprolyl isomerase A (cyclophilin A)-like 4; peptidylprolyl isomerase A (cyclophilin ...... |
Chromosomal Location | 1p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPIAL4A collected from DrugBank database. |
There is no record. |