Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum lumen Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). |
Domain |
PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
Biological Process |
GO:0000413 protein peptidyl-prolyl isomerization GO:0001501 skeletal system development GO:0006457 protein folding GO:0018208 peptidyl-proline modification GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0031647 regulation of protein stability GO:0035264 multicellular organism growth GO:0035821 modification of morphology or physiology of other organism GO:0040014 regulation of multicellular organism growth GO:0040018 positive regulation of multicellular organism growth GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044788 modulation by host of viral process GO:0044794 positive regulation by host of viral process GO:0044827 modulation by host of viral genome replication GO:0044829 positive regulation by host of viral genome replication GO:0045069 regulation of viral genome replication GO:0045070 positive regulation of viral genome replication GO:0045927 positive regulation of growth GO:0048524 positive regulation of viral process GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0050792 regulation of viral process GO:0050821 protein stabilization GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0060348 bone development GO:0061077 chaperone-mediated protein folding GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle |
Molecular Function |
GO:0003755 peptidyl-prolyl cis-trans isomerase activity GO:0005518 collagen binding GO:0016853 isomerase activity GO:0016859 cis-trans isomerase activity GO:0033218 amide binding GO:0042277 peptide binding GO:0051082 unfolded protein binding GO:0070063 RNA polymerase binding |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005790 smooth endoplasmic reticulum GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0034663 endoplasmic reticulum chaperone complex GO:0042470 melanosome GO:0048770 pigment granule |
KEGG | - |
Reactome |
R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization |
Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPIB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PPIB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPIB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPIB in various data sets.
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Points in the above scatter plot represent the mutation difference of PPIB in various data sets.
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Summary | |
---|---|
Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPIB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPIB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPIB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPIB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPIB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPIB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPIB |
Name | peptidylprolyl isomerase B (cyclophilin B) |
Aliases | CYPB; OI9; CYP-S1; HEL-S-39; SCYLP; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory ...... |
Chromosomal Location | 15q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPIB collected from DrugBank database. |
Details on drugs targeting PPIB.
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