TISIDB

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, cytosol Cell membrane Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
Domain	PF00328 Histidine phosphatase superfamily (branch 2)
Function	Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.

> Gene Ontology [ TOP ]
Biological Process	GO:0006020 inositol metabolic process GO:0006066 alcohol metabolic process GO:0016311 dephosphorylation GO:0019751 polyol metabolic process GO:0032958 inositol phosphate biosynthetic process GO:0043647 inositol phosphate metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process
Molecular Function	GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity GO:0000828 inositol hexakisphosphate kinase activity GO:0000829 inositol heptakisphosphate kinase activity GO:0000832 inositol hexakisphosphate 5-kinase activity GO:0003993 acid phosphatase activity GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0016791 phosphatase activity GO:0033857 diphosphoinositol-pentakisphosphate kinase activity GO:0042578 phosphoric ester hydrolase activity GO:0052723 inositol hexakisphosphate 1-kinase activity GO:0052724 inositol hexakisphosphate 3-kinase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04070 Phosphatidylinositol signaling system
Reactome	R-HSA-1483249: Inositol phosphate metabolism R-HSA-1430728: Metabolism R-HSA-1855167: Synthesis of pyrophosphates in the cytosol

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPIP5K1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PPIP5K1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PPIP5K1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.638	0.0362
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.898	0.398
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.448	0.58
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.019	0.939
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.02	0.993
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.061	0.982
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.338	0.316
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.917	0.514
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.239	0.873
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.488	0.665
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.655	0.692
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.095	0.272

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PPIP5K1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	4.1	-4.1	0.561
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	5.1	-5.1	0.549
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	11.8	-11.8	0.193
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	18.2	-18.2	0.199
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	7.1	-7.1	0.467
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPIP5K1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPIP5K1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPIP5K1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPIP5K1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPIP5K1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPIP5K1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPIP5K1
Name	diphosphoinositol pentakisphosphate kinase 1
Aliases	KIAA0377; VIP1; HISPPD2A; histidine acid phosphatase domain containing 2A; IP6K; hsVIP1; IP6 kinase; VIP1 ho ......
Chromosomal Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPIP5K1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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