Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm |
Domain |
PF00481 Protein phosphatase 2C |
Function |
Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. |
Biological Process |
GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPM1H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPM1H in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPM1H in various data sets.
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Points in the above scatter plot represent the mutation difference of PPM1H in various data sets.
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Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPM1H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPM1H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPM1H. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPM1H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPM1H expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPM1H and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPM1H |
Name | protein phosphatase, Mg2+/Mn2+ dependent, 1H |
Aliases | KIAA1157; FLJ13253; NERPP-2C; neurite extension-related protein phosphatase related to PP2C; ARHCL1; ras hom ...... |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPM1H collected from DrugBank database. |
There is no record. |