Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Nucleus, nucleoplasm Nucleus, nucleolus Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. |
Domain |
PF00149 Calcineurin-like phosphoesterase PF16891 Serine-threonine protein phosphatase N-terminal domain |
Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). |
Biological Process |
GO:0000086 G2/M transition of mitotic cell cycle GO:0000271 polysaccharide biosynthetic process GO:0000272 polysaccharide catabolic process GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0005978 glycogen biosynthetic process GO:0005979 regulation of glycogen biosynthetic process GO:0005980 glycogen catabolic process GO:0005981 regulation of glycogen catabolic process GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006109 regulation of carbohydrate metabolic process GO:0006112 energy reserve metabolic process GO:0006470 protein dephosphorylation GO:0007623 circadian rhythm GO:0009250 glucan biosynthetic process GO:0009251 glucan catabolic process GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009648 photoperiodism GO:0009649 entrainment of circadian clock GO:0009894 regulation of catabolic process GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010906 regulation of glucose metabolic process GO:0010962 regulation of glucan biosynthetic process GO:0015980 energy derivation by oxidation of organic compounds GO:0016051 carbohydrate biosynthetic process GO:0016052 carbohydrate catabolic process GO:0016311 dephosphorylation GO:0019318 hexose metabolic process GO:0031329 regulation of cellular catabolic process GO:0032881 regulation of polysaccharide metabolic process GO:0032885 regulation of polysaccharide biosynthetic process GO:0032922 circadian regulation of gene expression GO:0033692 cellular polysaccharide biosynthetic process GO:0034637 cellular carbohydrate biosynthetic process GO:0042752 regulation of circadian rhythm GO:0043153 entrainment of circadian clock by photoperiod GO:0043255 regulation of carbohydrate biosynthetic process GO:0043467 regulation of generation of precursor metabolites and energy GO:0043470 regulation of carbohydrate catabolic process GO:0043471 regulation of cellular carbohydrate catabolic process GO:0044042 glucan metabolic process GO:0044247 cellular polysaccharide catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044275 cellular carbohydrate catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0048511 rhythmic process GO:0070873 regulation of glycogen metabolic process |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0016791 phosphatase activity GO:0017018 myosin phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0050115 myosin-light-chain-phosphatase activity |
Cellular Component |
GO:0000164 protein phosphatase type 1 complex GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0008287 protein serine/threonine phosphatase complex GO:0030055 cell-substrate junction GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0042587 glycogen granule GO:0044454 nuclear chromosome part GO:0070688 MLL5-L complex GO:0072357 PTW/PP1 phosphatase complex GO:0098687 chromosomal region GO:1903293 phosphatase complex |
KEGG |
hsa03015 mRNA surveillance pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04114 Oocyte meiosis hsa04261 Adrenergic signaling in cardiomyocytes hsa04270 Vascular smooth muscle contraction hsa04390 Hippo signaling pathway hsa04510 Focal adhesion hsa04611 Platelet activation hsa04720 Long-term potentiation hsa04728 Dopaminergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04810 Regulation of actin cytoskeleton hsa04910 Insulin signaling pathway hsa04921 Oxytocin signaling pathway |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-400253: Circadian Clock R-HSA-2173788: Downregulation of TGF-beta receptor signaling R-HSA-69275: G2/M Transition R-HSA-163560: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-453274: Mitotic G2-G2/M phases R-HSA-195258: RHO GTPase Effectors R-HSA-5627117: RHO GTPases Activate ROCKs R-HSA-5627123: RHO GTPases activate PAKs R-HSA-5625740: RHO GTPases activate PKNs R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173789: TGF-beta receptor signaling activates SMADs |
Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPP1CB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPP1CB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPP1CB in various data sets.
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Points in the above scatter plot represent the mutation difference of PPP1CB in various data sets.
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Summary | |
---|---|
Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1CB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1CB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1CB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1CB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPP1CB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPP1CB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPP1CB |
Name | protein phosphatase 1, catalytic subunit, beta isozyme |
Aliases | PP1B; PP-1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; HEL-S-80p; PPP1CD; epididymis ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPP1CB collected from DrugBank database. |
There is no record. |