TISIDB

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Note=Along actomyosin filaments and stress fibers.
Domain	PF12796 Ankyrin repeats (3 copies) PF15898 cGMP-dependent protein kinase interacting domain
Function	Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

> Gene Ontology [ TOP ]
Biological Process	GO:0000086 G2/M transition of mitotic cell cycle GO:0003012 muscle system process GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0044057 regulation of system process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0090257 regulation of muscle system process
Molecular Function	GO:0008047 enzyme activator activity GO:0019208 phosphatase regulator activity
Cellular Component	GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031672 A band GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04270 Vascular smooth muscle contraction hsa04510 Focal adhesion hsa04810 Regulation of actin cytoskeleton hsa04921 Oxytocin signaling pathway
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-69275: G2/M Transition R-HSA-453274: Mitotic G2-G2/M phases R-HSA-195258: RHO GTPase Effectors R-HSA-5627117: RHO GTPases Activate ROCKs R-HSA-5627123: RHO GTPases activate PAKs R-HSA-5625740: RHO GTPases activate PKNs R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases

> KEGG and Reactome Pathway

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KEGG

hsa04270 Vascular smooth muscle contraction
hsa04510 Focal adhesion
hsa04810 Regulation of actin cytoskeleton
hsa04921 Oxytocin signaling pathway

Reactome

R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-69275: G2/M Transition
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-195258: RHO GTPase Effectors
R-HSA-5627117: RHO GTPases Activate ROCKs
R-HSA-5627123: RHO GTPases activate PAKs
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPP1R12B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PPP1R12B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PPP1R12B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.084	0.849
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.061	0.965
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.205	0.812
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.141	0.707
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.304	0.889
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.065	0.981
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.805	0.0413
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.992	0.549
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.657	0.713
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.534	0.596
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.486	0.258
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.004	0.958

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PPP1R12B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	4.1	10.7	0.0828
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	5.1	9.7	0.199
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R12B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R12B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R12B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R12B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPP1R12B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPP1R12B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPP1R12B
Name	protein phosphatase 1, regulatory subunit 12B
Aliases	MGC87886; MGC131980; PP1bp55; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2; M ......
Chromosomal Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPP1R12B collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse PPP1R12B