Browse PPP1R14A

Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF05361 PKC-activated protein phosphatase-1 inhibitor
Function

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

> Gene Ontology
 
Biological Process GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035303 regulation of dephosphorylation
GO:0035304 regulation of protein dephosphorylation
GO:0035690 cellular response to drug
GO:0042493 response to drug
Molecular Function GO:0004857 enzyme inhibitor activity
GO:0004864 protein phosphatase inhibitor activity
GO:0004865 protein serine/threonine phosphatase inhibitor activity
GO:0019208 phosphatase regulator activity
GO:0019212 phosphatase inhibitor activity
GO:0019888 protein phosphatase regulator activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04270 Vascular smooth muscle contraction
Reactome R-HSA-195258: RHO GTPase Effectors
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPP1R14A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPP1R14A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPP1R14A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.2260.00302
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.2750.0402
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4680.641
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7150.295
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4110.805
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.10.585
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1640.653
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2390.686
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1310.831
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8790.607
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2580.58
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3450.033
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PPP1R14A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R14A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R14A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R14A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R14A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPP1R14A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPP1R14A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPP1R14A
Nameprotein phosphatase 1, regulatory (inhibitor) subunit 14A
Aliases CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPP1R14A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.