Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF05361 PKC-activated protein phosphatase-1 inhibitor |
Function |
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
Biological Process |
GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035690 cellular response to drug GO:0042493 response to drug |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004864 protein phosphatase inhibitor activity GO:0004865 protein serine/threonine phosphatase inhibitor activity GO:0019208 phosphatase regulator activity GO:0019212 phosphatase inhibitor activity GO:0019888 protein phosphatase regulator activity |
Cellular Component | - |
KEGG |
hsa04270 Vascular smooth muscle contraction |
Reactome |
R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPP1R14A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPP1R14A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPP1R14A in various data sets.
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Points in the above scatter plot represent the mutation difference of PPP1R14A in various data sets.
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Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R14A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R14A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R14A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R14A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPP1R14A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPP1R14A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPP1R14A |
Name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
Aliases | CPI-17; 17-kDa PKC-potentiated inhibitory protein of PP1; PKC-potentiated inhibitory protein of PP1; 17-KDa ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPP1R14A collected from DrugBank database. |
There is no record. |